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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Deep Track Capital LP	[2025-06-30]	SOLE	8,831,007	8,831,007
RTW Investments LP	[2025-06-30]	SOLE	8,221,929	8,221,929
Nantahala Capital Management LLC	[2025-06-30]	SOLE	4,179,930	4,179,930
Vivo Capital LLC	[2025-06-30]	SOLE	3,362,385	3,362,385
Millennium Management LLC	[2025-06-30]	SOLE	1,741,782	1,941,782
GMT Capital Corp	[2025-06-30]	SOLE	1,781,718	1,781,718
PFM Health Sciences LP	[2025-06-30]	DFND	0	1,779,259
Woodline Partners LP	[2025-06-30]	SOLE	1,755,938	1,755,938
UBS Group AG	[2025-06-30]	DFND	1,677,610	1,678,608
ARK Investment Management LLC	[2025-06-30]	SOLE	1,649,221	1,649,221
Ally Bridge Group NY LLC	[2025-06-30]	SOLE	1,485,000	1,485,000
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,300,000
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	1,300,000
Aisling Capital Management LP	[2025-06-30]	SOLE	1,198,418	1,198,418
HSBC Holdings PLC	[2025-06-30]	SOLE	1,075,485	1,075,485
22NW LP	[2025-06-30]	SOLE	882,844	882,844
Balyasny Asset Management LP	[2025-06-30]	SOLE	854,840	854,840
DAFNA Capital Management LLC	[2025-06-30]	SOLE	811,046	811,046
Susquehanna International Group LLP	[2025-06-30]	OTR	108,557	640,057
Schroder Investment Management Group	[2025-06-30]	SOLE	544,721	544,721
Toronto Dominion Bank	[2025-06-30]	DFND	0	500,000
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	482,651	482,651
Barclays PLC	[2025-06-30]	DFND	0	410,476
Susquehanna Portfolio Strategies, LLC	[2025-06-30]	SOLE	399,963	399,963
Goldman Sachs Group Inc	[2025-06-30]	DFND	386,693	386,693
BlackRock, Inc.	[2025-06-30]	SOLE	377,060	377,060
Citadel Advisors LLC	[2025-06-30]	DFND	372,602	372,602
Walleye Trading LLC	[2025-06-30]	SOLE	284,000	284,000
Founders Fund VII Management, LLC	[2025-06-30]	SOLE	278,880	278,880
Morgan Stanley	[2025-06-30]	DFND	83,848	265,833
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