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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	5,012,118.0
BlackRock Inc.	[2023-03-31]	SOLE	4,649,607.0	4,754,563.0
State Street Corp	[2023-03-31]	DFND	3,297,492.0	3,355,292.0
Avidity Partners Management LP	[2023-03-31]	SOLE	2,758,600.0	2,758,600.0
Rokos Capital Management LLP	[2023-03-31]	OTR	0.0	2,748,139.0
Bank of America Corp /DE/	[2023-03-31]	DFND	12,024.0	2,632,385.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,522,882.0
Elmwood Wealth Management Inc	[2023-03-31]	SOLE	2,364,240.0	2,364,240.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	2,066,176.0
FMR LLC	[2023-03-31]	DFND	1,443,717.0	1,443,823.0
Morgan Stanley	[2023-03-31]	DFND	1,241,652.0	1,249,248.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,069,624.0	1,069,624.0
Alkeon Capital Management LLC	[2023-03-31]	SOLE	889,466.0	889,466.0
FIL Ltd	[2023-03-31]	DFND	860,666.0	860,666.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	843,025.0	843,025.0
Maverick Capital Ltd	[2023-03-31]	SOLE	652,542.0	652,542.0
JPMorgan Chase & Co	[2023-03-31]	DFND	559,751.0	602,978.0
Tekla Capital Management LLC	[2023-03-31]	SOLE	3,011,551.0	567,147.0
Memorial Sloan Kettering Cancer Center	[2023-03-31]	SOLE	544,196.0	544,196.0
Northern Trust Corp	[2023-03-31]	DFND	20,574.0	527,342.0
72 Investment Holdings, LLC	[2023-03-31]	DFND	0.0	474,067.0
International Biotechnology Trust PLC	[2023-03-31]	SOLE	457,892.0	457,892.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	410,449.0	410,449.0
Millennium Management LLC	[2023-03-31]	SOLE	325,015.0	325,015.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	313,769.0	313,769.0
Citadel Advisors LLC	[2023-03-31]	DFND	307,950.0	307,950.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	292,964.0	292,964.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	289,739.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	287,033.0	287,033.0
Rafferty Asset Management LLC	[2023-03-31]	SOLE	233,783.0	233,783.0
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