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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Driehaus Capital Management LLC	[2023-03-31]	SOLE	4,827,650.0	5,289,519.0
BlackRock Inc.	[2023-03-31]	SOLE	3,859,304.0	3,956,358.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	3,196,876.0	3,950,796.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	3,635,526.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	3,554,887.0	3,554,887.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	2,736,613.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,618,824.0
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	2,305,558.0	2,305,558.0
State Street Corp	[2023-03-31]	DFND	2,120,624.0	2,218,794.0
Braidwell LP	[2023-03-31]	SOLE	2,019,714.0	2,019,714.0
First Light Asset Management LLC	[2023-03-31]	SOLE	1,619,125.0	1,619,125.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	1,414,823.0	1,414,823.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	1,330,263.0	1,330,263.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	1,133,782.0	1,133,782.0
Novo Holdings A/S	[2023-03-31]	SOLE	1,100,000.0	1,100,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	954,860.0	954,860.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	275,694.0	929,369.0
FMR LLC	[2023-03-31]	DFND	919,632.0	920,958.0
Finepoint Capital LP	[2023-03-31]	SOLE	868,427.0	868,427.0
5AM Venture Management LLC	[2023-03-31]	SOLE	862,286.0	862,286.0
Opaleye Management Inc	[2023-03-31]	SOLE	785,794.0	785,794.0
Saturn V Capital Management LLC	[2023-03-31]	SOLE	741,043.0	741,043.0
BNP Paribas Asset Management Holding S.A.	[2023-03-31]	DFND	0.0	691,201.0
Morgan Stanley	[2023-03-31]	DFND	647,500.0	652,916.0
GW&K Investment Management LLC	[2023-03-31]	SOLE	536,880.0	536,880.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	520,168.0	520,198.0
Northern Trust Corp	[2023-03-31]	DFND	21,282.0	477,018.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	434,768.0	434,768.0
Walleye Capital LLC	[2023-03-31]	SOLE	433,695.0	433,695.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	375,389.0	416,457.0
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