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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2025-06-30]	SOLE	7,165,006	7,165,006
Point72 Asset Management LP	[2025-06-30]	DFND	0	7,042,373
BlackRock, Inc.	[2025-06-30]	SOLE	4,136,426	4,238,410
Adams Street Partners LLC	[2025-06-30]	SOLE	3,275,616	3,275,616
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,212,383
RTW Investments LP	[2025-06-30]	SOLE	2,679,479	2,679,479
Vivo Capital LLC	[2025-06-30]	SOLE	2,234,566	2,234,566
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	1,731,233	1,731,233
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,438,595	1,438,595
Geode Capital Management LLC	[2025-06-30]	DFND	1,361,740	1,361,740
Morgan Stanley	[2025-06-30]	DFND	423,123	894,405
DCF Advisers, LLC	[2025-06-30]	SOLE	760,000	760,000
State Street Corp	[2025-06-30]	DFND	594,036	664,768
Northern Trust Corp	[2025-06-30]	DFND	395,139	395,139
Barclays PLC	[2025-06-30]	SOLE	343,526	343,526
GSA Capital Partners LLP	[2025-06-30]	SOLE	318,732	318,732
Two Sigma Investments LP	[2025-06-30]	SOLE	223,913	223,913
Two Sigma Advisers LP	[2025-06-30]	SOLE	198,200	212,700
Marshall Wace LLP	[2025-06-30]	OTR	0	201,651
Sphera Funds Management Ltd	[2025-06-30]	DFND	183,094	183,094
Goldman Sachs Group Inc	[2025-06-30]	DFND	170,211	170,211
Towerview LLC	[2025-06-30]	SOLE	170,000	170,000
Empirical Financial Services, LLC d.b.a. Empirical Wealth Ma	[2025-06-30]	SOLE	168,000	168,000
Renaissance Technologies LLC	[2025-06-30]	SOLE	165,188	165,188
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	161,821	161,821
Millennium Management LLC	[2025-06-30]	SOLE	0	150,000
Squarepoint Ops LLC	[2025-06-30]	DFND	0	138,462
Susquehanna International Group LLP	[2025-06-30]	OTR	67,816	137,816
Bank of America Corp /DE/	[2025-06-30]	DFND	3,251	132,729
Raymond James Financial Inc	[2025-06-30]	DFND	19,469	124,496
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