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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2023-03-31]	SOLE	14,614,264.0	14,614,264.0
Braidwell LP	[2023-03-31]	SOLE	12,107,785.0	12,107,785.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	7,064,964.0	7,064,964.0
Vivo Capital LLC	[2023-03-31]	SOLE	2,708,875.0	2,708,875.0
Boxer Capital, LLC	[2023-03-31]	OTR	1,450,000.0	1,450,000.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	1,202,623.0
BlackRock Inc.	[2023-03-31]	SOLE	973,256.0	973,256.0
Millennium Management LLC	[2023-03-31]	SOLE	872,637.0	872,637.0
Morgan Stanley	[2023-03-31]	DFND	484,376.0	524,975.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	370,950.0	370,950.0
Commodore Capital LP	[2023-03-31]	SOLE	92,687.0	92,687.0
Cowen and Company LLC	[2023-03-31]	DFND	50,986.0	50,986.0
Envestnet Asset Management Inc	[2023-03-31]	SOLE	36,638.0	36,638.0
Old Mission Capital LLC	[2023-03-31]	DFND	30,597.0	30,597.0
Geode Capital Management LLC	[2023-03-31]	DFND	23,666.0	23,666.0
Janney Montgomery Scott LLC	[2023-03-31]	SOLE	23,546.0	23,546.0
BNP Paribas Arbitrage SNC	[2023-03-31]	DFND	0.0	22,408.0
Commonwealth Equity Services LLC	[2023-03-31]	SOLE	0.0	15,700.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	0.0	14,400.0
Choreo LLC	[2023-03-31]	SOLE	0.0	10,000.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	7,233.0	7,233.0
Heritage Wealth Advisors	[2023-03-31]	SOLE	0.0	6,000.0
Barclays PLC	[2023-03-31]	SOLE	3,265.0	3,265.0
Cutler Group LLC / CA	[2023-03-31]	SOLE	3,100.0	3,100.0
Bank of America Corp /DE/	[2023-03-31]	DFND	1,230.0	1,966.0
Advisory Services Network LLC	[2023-03-31]	SOLE	1,000.0	1,000.0
Advisor Group Holdings Inc	[2023-03-31]	DFND	0.0	855.0
Royal Bank of Canada	[2023-03-31]	DFND	716.0	716.0
Mark Sheptoff Financial Planning LLC	[2023-03-31]	SOLE	300.0	300.0
Group One Trading LP	[2023-03-31]	SOLE	277.0	277.0
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