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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Redmile Group LLC	[2023-03-31]	SOLE	5,582,105.0	5,582,105.0
BlackRock Inc.	[2023-03-31]	SOLE	5,311,065.0	5,544,988.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	5,218,638.0	5,218,638.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	4,503,925.0
Armistice Capital LLC	[2023-03-31]	SOLE	4,100,000.0	4,100,000.0
State Street Corp	[2023-03-31]	DFND	3,218,673.0	3,322,150.0
Braidwell LP	[2023-03-31]	SOLE	3,241,351.0	3,241,351.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	3,057,873.0	3,057,913.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	1,750,000.0	1,750,000.0
Deep Track Capital LP	[2023-03-31]	SOLE	1,363,201.0	1,363,201.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	1,321,016.0	1,321,016.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,218,261.0	1,287,240.0
New Leaf Venture Partners LLC	[2023-03-31]	DFND	1,209,571.0	1,209,571.0
Jefferies Financial Group Inc.	[2023-03-31]	DFND	1,175,118.0	1,175,118.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,066,104.0	1,066,104.0
Morgan Stanley	[2023-03-31]	DFND	807,707.0	933,796.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	711,075.0	878,137.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	848,632.0	848,632.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	789,886.0	790,786.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	129,861.0	589,855.0
Northern Trust Corp	[2023-03-31]	DFND	29,669.0	505,196.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	491,772.0	491,772.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	408,900.0	475,700.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	456,645.0	456,645.0
ExodusPoint Capital Management LP	[2023-03-31]	OTR	0.0	434,670.0
Woodline Partners LP	[2023-03-31]	SOLE	339,905.0	339,905.0
Bank of America Corp /DE/	[2023-03-31]	DFND	32,661.0	333,873.0
UBS Asset Management Americas Inc	[2023-03-31]	DFND	240,142.0	290,116.0
Hillsdale Investment Management Inc	[2023-03-31]	SOLE	253,200.0	253,200.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	247,238.0	247,238.0
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