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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	7,856,612.0
FMR LLC	[2023-03-31]	DFND	5,680,254.0	5,680,540.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	3,950,000.0	3,950,000.0
Northpond Ventures LLC	[2023-03-31]	SOLE	3,292,871.0	3,292,871.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	581,630.0	3,197,179.0
BlackRock Inc.	[2023-03-31]	SOLE	2,940,589.0	3,012,441.0
Sands Capital Ventures LLC	[2023-03-31]	SOLE	2,748,970.0	2,748,970.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	1,724,461.0	2,001,553.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,874,265.0
Deep Track Capital LP	[2023-03-31]	SOLE	1,600,000.0	1,600,000.0
Armistice Capital LLC	[2023-03-31]	SOLE	1,376,000.0	1,376,000.0
Woodline Partners LP	[2023-03-31]	SOLE	1,192,177.0	1,192,177.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	1,159,664.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,035,786.0	1,035,786.0
Braidwell LP	[2023-03-31]	SOLE	984,800.0	984,800.0
Alkeon Capital Management LLC	[2023-03-31]	SOLE	871,124.0	871,124.0
VR Adviser LLC	[2023-03-31]	SOLE	819,000.0	819,000.0
State Street Corp	[2023-03-31]	DFND	736,284.0	798,284.0
Geode Capital Management LLC	[2023-03-31]	DFND	695,933.0	695,933.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	556,241.0	556,241.0
Novo Holdings A/S	[2023-03-31]	SOLE	536,100.0	536,100.0
Nicholas Investment Partners LP	[2023-03-31]	SOLE	416,151.0	416,151.0
ArrowMark Colorado Holdings LLC	[2023-03-31]	SOLE	412,209.0	412,209.0
Logos Global Management LP	[2023-03-31]	SOLE	410,000.0	410,000.0
New Leaf Venture Partners LLC	[2023-03-31]	DFND	371,693.0	371,693.0
Franklin Resources Inc	[2023-03-31]	DFND	336,358.0	336,358.0
Casdin Capital LLC	[2023-03-31]	SOLE	310,000.0	310,000.0
Northern Trust Corp	[2023-03-31]	DFND	12,967.0	308,997.0
Millennium Management LLC	[2023-03-31]	SOLE	271,574.0	301,774.0
OUP Management Co LLC	[2023-03-31]	SOLE	268,346.0	268,346.0
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