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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
SR One Capital Management LP	[2025-06-30]	SOLE	6,526,476	6,526,476
Logos Global Management LP	[2025-06-30]	SOLE	4,217,627	4,217,627
BlackRock, Inc.	[2025-06-30]	SOLE	2,297,709	2,395,743
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	1,953,547	1,953,547
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,807,218
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,780,975
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,712,882	1,712,882
Almitas Capital LLC	[2025-06-30]	SOLE	1,530,435	1,530,435
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,446,561
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,076,236	1,076,236
Kynam Capital Management LP	[2025-06-30]	SOLE	1,029,579	1,029,579
FMR LLC	[2025-06-30]	DFND	945,245	951,198
Citadel Advisors LLC	[2025-06-30]	DFND	840,793	840,793
Geode Capital Management LLC	[2025-06-30]	DFND	794,008	794,008
Woodline Partners LP	[2025-06-30]	SOLE	777,537	777,537
State Street Corp	[2025-06-30]	DFND	682,412	719,212
Acadian Asset Management LLC	[2025-06-30]	DFND	627,348	627,348
MPM BioImpact LLC	[2025-06-30]	SOLE	555,187	555,187
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	390,081	390,648
Northern Trust Corp	[2025-06-30]	DFND	357,392	357,392
Renaissance Technologies LLC	[2025-06-30]	SOLE	267,800	267,800
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	220,632	261,899
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	250,949	250,949
Goldman Sachs Group Inc	[2025-06-30]	DFND	239,459	239,459
Morgan Stanley	[2025-06-30]	DFND	210,394	213,550
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	188,200	188,200
Nuveen, LLC	[2025-06-30]	DFND	133,028	133,028
Barclays PLC	[2025-06-30]	SOLE	109,536	109,536
Two Sigma Advisers LP	[2025-06-30]	SOLE	99,800	108,500
Bank of New York Mellon Corp	[2025-06-30]	DFND	65,065	94,603
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