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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	13,150,849.0
BML Capital Management LLC	[2023-03-31]	SOLE	0.0	1,658,170.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	673,684.0	673,684.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	485,955.0	485,955.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	272,889.0
Atom Investors LP	[2023-03-31]	SOLE	78,886.0	78,886.0
Millennium Management LLC	[2023-03-31]	SOLE	67,621.0	67,621.0
Geode Capital Management LLC	[2023-03-31]	DFND	64,014.0	64,014.0
Morgan Stanley	[2023-03-31]	DFND	62,316.0	62,316.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	55,223.0	55,223.0
BlackRock Inc.	[2023-03-31]	SOLE	32,701.0	32,701.0
Tudor Investment Corp ET AL	[2023-03-31]	DFND	86.0	29,706.0
State Street Corp	[2023-03-31]	DFND	19,800.0	19,800.0
Chicago Partners Investment Group LLC	[2023-03-31]	SOLE	0.0	18,520.0
Stifel Financial Corp	[2023-03-31]	DFND	13,362.0	14,862.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	11,247.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	3,262.0	3,262.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	1,628.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	695.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	42.0	42.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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