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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FCPM III Services BV	[2024-06-30]	DFND	0.0	8,677,951.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	3,300,000.0	3,300,000.0
VR Adviser LLC	[2024-06-30]	SOLE	2,825,983.0	2,825,983.0
Blue Owl Capital Holdings LP	[2024-06-30]	DFND	0.0	2,449,827.0
Logos Global Management LP	[2024-06-30]	SOLE	2,400,000.0	2,400,000.0
BVF Inc/IL	[2024-06-30]	DFND	0.0	2,251,037.0
Deep Track Capital LP	[2024-06-30]	SOLE	2,250,000.0	2,250,000.0
Omega Fund Management LLC	[2024-06-30]	SOLE	1,076,357.0	1,076,357.0
Janus Henderson Group PLC	[2024-06-30]	DFND	0.0	1,000,000.0
Cormorant Asset Management LP	[2024-06-30]	DFND	1,000,000.0	1,000,000.0
Franklin Resources Inc	[2024-06-30]	DFND	800,034.0	800,034.0
Soleus Capital Management LP	[2024-06-30]	SOLE	800,000.0	800,000.0
Perceptive Advisors LLC	[2024-06-30]	SOLE	800,000.0	800,000.0
Marshall Wace LLP	[2024-06-30]	OTR	0.0	764,645.0
Boxer Capital, LLC	[2024-06-30]	OTR	727,900.0	727,900.0
Vivo Capital LLC	[2024-06-30]	SOLE	678,705.0	678,705.0
Citadel Advisors LLC	[2024-06-30]	DFND	613,292.0	613,292.0
SR One Capital Management LP	[2024-06-30]	SOLE	500,000.0	500,000.0
Ghost Tree Capital LLC	[2024-06-30]	SOLE	420,331.0	420,331.0
SilverArc Capital Management LLC	[2024-06-30]	SOLE	263,841.0	263,841.0
Schonfeld Strategic Advisors LLC	[2024-06-30]	SOLE	97,000.0	97,000.0
Point72 Asset Management LP	[2024-06-30]	DFND	0.0	43,900.0
Geode Capital Management LLC	[2024-06-30]	DFND	27,516.0	27,516.0
Verition Fund Management LLC	[2024-06-30]	SOLE	14,843.0	14,843.0
Ameriprise Financial Inc	[2024-06-30]	DFND	0.0	12,524.0
Royal Bank of Canada	[2024-06-30]	DFND	0.0	7,915.0
UBS Group AG	[2024-06-30]	SOLE	3,370.0	3,370.0
Wells Fargo & Company/MN	[2024-06-30]	DFND	0.0	972.0
Adar1 Capital Management LLC	[2024-06-30]	SOLE	600.0	600.0
Morgan Stanley	[2024-06-30]	DFND	8.0	58.0
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