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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Knoll Capital Management, LLC	[2025-06-30]	SOLE	5,881,879	5,881,879
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,697,236
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	604,522	604,522
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	355,822	355,822
Northern Trust Corp	[2025-06-30]	DFND	200,745	200,745
Bessemer Group Inc	[2025-06-30]	DFND	140,843	140,843
Hightower Advisors LLC	[2025-06-30]	SOLE	67,544	67,544
Renaissance Technologies LLC	[2025-06-30]	SOLE	64,300	64,300
Susquehanna International Group LLP	[2025-06-30]	OTR	48,877	48,877
Signature Estate & Investment Advisors LLC	[2025-06-30]	DFND	0	47,328
Bank of America Corp /DE/	[2025-06-30]	DFND	0	23,430
Geode Capital Management LLC	[2025-06-30]	DFND	21,136	21,136
UBS Group AG	[2025-06-30]	DFND	15,631	15,631
Citadel Advisors LLC	[2025-06-30]	DFND	11,656	11,656
Jane Street Group LLC	[2025-06-30]	DFND	10,187	10,187
PNC Financial Services Group Inc	[2025-06-30]	DFND	10,000	10,000
Newedge Advisors LLC	[2025-06-30]	SOLE	0	9,000
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	815
Group One Trading LLC	[2025-06-30]	SOLE	51	51
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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