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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	22,729,436	22,729,436
VR Adviser LLC	[2025-06-30]	SOLE	17,857,083	17,857,083
BlackRock, Inc.	[2025-06-30]	SOLE	14,728,791	15,166,198
Logos Global Management LP	[2025-06-30]	SOLE	15,000,000	15,000,000
Suvretta Capital Management LLC	[2025-06-30]	SOLE	14,502,004	14,502,004
Vanguard Group Inc	[2025-06-30]	SOLE	0	12,543,132
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	11,907,182	11,907,182
Arch Venture Management LLC	[2025-06-30]	SOLE	0	11,055,554
Siren, L.L.C.	[2025-06-30]	DFND	8,757,249	8,757,249
Vivo Capital LLC	[2025-06-30]	SOLE	6,756,756	6,756,756
5AM Venture Management LLC	[2025-06-30]	SOLE	5,405,404	5,405,404
Geode Capital Management LLC	[2025-06-30]	DFND	4,835,642	4,835,642
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	4,085,787	4,085,787
Millennium Management LLC	[2025-06-30]	SOLE	3,797,987	4,030,687
State Street Corp	[2025-06-30]	DFND	3,827,010	4,002,110
Ah Capital Management LLC	[2025-06-30]	SOLE	2,862,500	2,862,500
SilverArc Capital Management LLC	[2025-06-30]	SOLE	2,569,591	2,569,591
Soleus Capital Management LP	[2025-06-30]	SOLE	2,162,162	2,162,162
Marshall Wace LLP	[2025-06-30]	OTR	0	2,074,425
Woodline Partners LP	[2025-06-30]	SOLE	2,074,390	2,074,390
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,766,673	1,766,963
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,696,593	1,696,593
Bank of America Corp /DE/	[2025-06-30]	DFND	8,432	1,571,325
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,320,017	1,518,553
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,502,915
Northern Trust Corp	[2025-06-30]	DFND	1,381,102	1,382,436
JPMorgan Chase & Co	[2025-06-30]	DFND	1,140,937	1,372,569
SIO Capital Management LLC	[2025-06-30]	SOLE	1,369,748	1,369,748
PFM Health Sciences LP	[2025-06-30]	DFND	0	1,072,224
Wellington Management Group LLP	[2025-06-30]	DFND	0	885,651
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