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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	20,788,363
RA Capital Management LP	[2025-06-30]	SOLE	19,889,683	19,889,683
Suvretta Capital Management LLC	[2025-06-30]	SOLE	14,210,000	14,210,000
BlackRock, Inc.	[2025-06-30]	SOLE	10,307,169	10,569,424
Deep Track Capital LP	[2025-06-30]	SOLE	9,500,000	9,500,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,033,556
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	6,750,000	6,750,000
State Street Corp	[2025-06-30]	DFND	3,956,806	4,249,957
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	3,757,571	4,035,390
Citadel Advisors LLC	[2025-06-30]	DFND	3,941,992	3,941,992
Westfield Capital Management Co LP	[2025-06-30]	SOLE	3,013,934	3,370,817
Geode Capital Management LLC	[2025-06-30]	DFND	3,111,299	3,111,299
Holocene Advisors LP	[2025-06-30]	SOLE	3,065,387	3,065,387
Polar Capital Holdings Plc	[2025-06-30]	DFND	2,475,000	2,475,000
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,274,151
Morgan Stanley	[2025-06-30]	DFND	2,177,062	2,185,005
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	2,171,194	2,171,194
SilverArc Capital Management LLC	[2025-06-30]	SOLE	2,037,087	2,037,087
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,969,000	1,969,000
RTW Investments LP	[2025-06-30]	SOLE	1,967,527	1,967,527
Emerald Advisers LLC	[2025-06-30]	SOLE	1,385,090	1,844,370
Redmile Group LLC	[2025-06-30]	SOLE	1,545,208	1,545,208
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,252,369	1,253,085
Bank of America Corp /DE/	[2025-06-30]	DFND	21,806	1,249,954
Woodline Partners LP	[2025-06-30]	SOLE	1,222,661	1,222,661
University of Wisconsin Foundation	[2025-06-30]	SOLE	1,153,357	1,153,357
Emerald Mutual Fund Advisers Trust	[2025-06-30]	SOLE	1,145,813	1,145,813
Millennium Management LLC	[2025-06-30]	SOLE	962,474	1,132,474
Northern Trust Corp	[2025-06-30]	DFND	1,112,518	1,113,132
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	982,959	1,074,319
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