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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	11,416,948.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	3,746,038.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	3,175,000.0	3,175,000.0
State Street Corp	[2023-03-31]	DFND	3,070,374.0	3,070,374.0
Cormorant Asset Management LP	[2023-03-31]	DFND	2,800,000.0	2,800,000.0
Holocene Advisors LP	[2023-03-31]	SOLE	2,655,043.0	2,655,043.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,587,156.0
Federated Hermes Inc	[2023-03-31]	DFND	2,353,115.0	2,353,115.0
Caption Management LLC	[2023-03-31]	SOLE	2,313,238.0	2,313,238.0
Suvretta Capital Management LLC	[2023-03-31]	SOLE	2,210,536.0	2,210,536.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,179,155.0	2,179,155.0
Boxer Capital, LLC	[2023-03-31]	OTR	2,100,000.0	2,100,000.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	1,846,154.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,842,976.0	1,842,976.0
Deep Track Capital LP	[2023-03-31]	SOLE	1,804,400.0	1,804,400.0
Millennium Management LLC	[2023-03-31]	SOLE	1,543,647.0	1,689,347.0
Morgan Stanley	[2023-03-31]	DFND	1,536,753.0	1,612,839.0
Susquehanna International Group LLP	[2023-03-31]	DFND	644,101.0	1,294,801.0
BlackRock Inc.	[2023-03-31]	SOLE	1,241,502.0	1,249,572.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	1,129,471.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,021,647.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	976,551.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	806,300.0	901,100.0
Redmile Group LLC	[2023-03-31]	SOLE	900,000.0	900,000.0
Two Sigma Investments LP	[2023-03-31]	SOLE	867,961.0	867,961.0
Westfield Capital Management Co LP	[2023-03-31]	SOLE	617,080.0	755,210.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	561,157.0	741,994.0
Franklin Resources Inc	[2023-03-31]	DFND	710,832.0	710,832.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	642,073.0	642,073.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	638,215.0	638,215.0
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