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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	4,629,289
RA Capital Management LP	[2025-06-30]	SOLE	4,563,211	4,563,211
Goldman Sachs Group Inc	[2025-06-30]	DFND	4,159,264	4,159,264
BlackRock, Inc.	[2025-06-30]	SOLE	3,881,636	4,010,755
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,706,229
Novo Holdings A/S	[2025-06-30]	SOLE	2,000,000	2,000,000
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,754,410
Federated Hermes Inc	[2025-06-30]	DFND	1,667,338	1,667,338
Millennium Management LLC	[2025-06-30]	SOLE	1,483,724	1,483,724
State Street Corp	[2025-06-30]	DFND	904,762	961,962
Morgan Stanley	[2025-06-30]	DFND	910,121	924,676
Geode Capital Management LLC	[2025-06-30]	DFND	918,533	918,533
Bank of America Corp /DE/	[2025-06-30]	DFND	6,993	900,070
JPMorgan Chase & Co	[2025-06-30]	DFND	868,931	888,016
Two Sigma Advisers LP	[2025-06-30]	SOLE	713,500	743,400
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	648,825	648,825
Two Sigma Investments LP	[2025-06-30]	SOLE	531,163	531,163
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	514,614	514,614
Raymond James Financial Inc	[2025-06-30]	DFND	0	455,470
Acadian Asset Management LLC	[2025-06-30]	DFND	330,591	330,591
Northern Trust Corp	[2025-06-30]	DFND	322,438	322,438
Peapod Lane Capital LLC	[2025-06-30]	SOLE	254,261	318,537
Armistice Capital LLC	[2025-06-30]	SOLE	300,000	300,000
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	295,041	295,041
Marshall Wace LLP	[2025-06-30]	OTR	0	257,620
Citadel Advisors LLC	[2025-06-30]	DFND	246,039	246,039
Decheng Capital LLC	[2025-06-30]	SOLE	239,510	239,510
Deutsche Bank AG	[2025-06-30]	DFND	198,000	226,939
Privium Fund Management B.V.	[2025-06-30]	SOLE	197,458	197,458
Jane Street Group LLC	[2025-06-30]	DFND	190,373	190,373
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