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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	8,827,712
RA Capital Management LP	[2025-06-30]	SOLE	7,676,697	7,676,697
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	6,746,951
RTW Investments LP	[2025-06-30]	SOLE	5,540,457	5,540,457
FMR LLC	[2025-06-30]	DFND	5,092,145	5,092,145
Cormorant Asset Management LP	[2025-06-30]	DFND	2,009,482	2,009,482
Deep Track Capital LP	[2025-06-30]	SOLE	2,000,000	2,000,000
Toronto Dominion Bank	[2025-06-30]	DFND	0	1,967,293
Jefferies Financial Group Inc.	[2025-06-30]	DFND	709,312	709,312
Verition Fund Management LLC	[2025-06-30]	SOLE	657,381	657,381
5AM Venture Management LLC	[2025-06-30]	SOLE	572,665	572,665
UBS Group AG	[2025-06-30]	DFND	458,582	458,582
Morgan Stanley	[2025-06-30]	DFND	273,636	281,002
Alyeska Investment Group LP	[2025-06-30]	SOLE	254,975	254,975
Millennium Management LLC	[2025-06-30]	SOLE	203,645	203,645
Stempoint Capital LP	[2025-06-30]	SOLE	100,826	100,826
Troluce Capital Advisors LLC	[2025-06-30]	SOLE	85,791	85,791
BlackRock, Inc.	[2025-06-30]	SOLE	64,745	64,745
	[2025-06-30]	SOLE	52,247	52,247
Northern Trust Corp	[2025-06-30]	DFND	38,977	38,977
Advisorshares Investments LLC	[2025-06-30]	SOLE	38,256	38,256
Geode Capital Management LLC	[2025-06-30]	DFND	34,633	34,633
Hightower Advisors LLC	[2025-06-30]	SOLE	22,300	22,300
Palumbo Wealth Management LLC	[2025-06-30]	SOLE	0	21,651
Quadrature Capital Ltd	[2025-06-30]	OTR	0	20,108
Peak6 LLC	[2025-06-30]	DFND	20,000	20,000
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	17,010
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	13,833
Virtus Investment Advisers, LLC	[2025-06-30]	OTR	0	7,329
JPMorgan Chase & Co	[2025-06-30]	DFND	6,500	6,500
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