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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	6,166,271	6,167,666
BlackRock, Inc.	[2025-06-30]	SOLE	5,620,009	5,770,692
Redmile Group LLC	[2025-06-30]	SOLE	4,872,225	4,872,225
Enavate Sciences GP, LLC	[2025-06-30]	SOLE	4,768,583	4,768,583
Point72 Asset Management LP	[2025-06-30]	DFND	0	4,685,803
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,353,438
Toronto Dominion Bank	[2025-06-30]	SOLE	4,171,400	4,171,400
Jefferies Financial Group Inc.	[2025-06-30]	DFND	4,171,360	4,171,360
EcoR1 Capital LLC	[2025-06-30]	SOLE	4,079,415	4,079,415
Opaleye Management Inc	[2025-06-30]	SOLE	3,529,581	3,529,581
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	3,020,210	3,020,210
State Street Corp	[2025-06-30]	DFND	2,385,790	2,520,916
Geode Capital Management LLC	[2025-06-30]	DFND	1,860,580	1,860,580
Woodline Partners LP	[2025-06-30]	SOLE	1,658,663	1,658,663
Readystate Asset Management LP	[2025-06-30]	SOLE	1,353,586	1,353,586
Marshall Wace LLP	[2025-06-30]	OTR	0	1,297,752
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,040,414
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,000,000	1,000,000
Sofinnova Investments Inc	[2025-06-30]	SOLE	778,476	778,476
Northern Trust Corp	[2025-06-30]	DFND	679,810	679,810
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	640,249	640,249
TD Asset Management Inc	[2025-06-30]	SOLE	605,530	605,530
JPMorgan Chase & Co	[2025-06-30]	DFND	490,842	575,699
NAN FUNG TRINITY (HK) Ltd	[2025-06-30]	SOLE	548,850	548,850
Goldman Sachs Group Inc	[2025-06-30]	DFND	478,448	478,618
UBS Group AG	[2025-06-30]	DFND	425,515	425,915
Morgan Stanley	[2025-06-30]	DFND	305,420	404,357
Granahan Investment Management LLC	[2025-06-30]	SOLE	353,611	392,751
Principal Financial Group Inc	[2025-06-30]	DFND	342,791	342,791
Candriam S.C.A.	[2025-06-30]	SOLE	318,086	318,086
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