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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Aberdeen Group plc	[2025-06-30]	DFND	8,243,941	8,243,941
BVF Inc/IL	[2025-06-30]	DFND	0	7,652,972
Soleus Capital Management LP	[2025-06-30]	SOLE	7,293,007	7,293,007
Avidity Partners Management LP	[2025-06-30]	SOLE	5,615,811	5,615,811
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,093,281
Morgan Stanley	[2025-06-30]	DFND	3,603,528	3,628,528
Focus Partners Wealth	[2025-06-30]	SOLE	2,537,020	2,542,524
Laurion Capital Management LP	[2025-06-30]	SOLE	1,905,063	1,905,063
Omega Fund Management LLC	[2025-06-30]	SOLE	1,788,160	1,788,160
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,398,600	1,398,600
Geode Capital Management LLC	[2025-06-30]	DFND	974,636	974,636
Ikarian Capital LLC	[2025-06-30]	SOLE	914,170	914,170
Ghisallo Capital Management LLC	[2025-06-30]	SOLE	835,000	835,000
BlackRock, Inc.	[2025-06-30]	SOLE	698,739	698,739
RTW Investments LP	[2025-06-30]	SOLE	402,107	402,107
UBS Group AG	[2025-06-30]	DFND	376,104	376,104
State Street Corp	[2025-06-30]	DFND	331,945	331,945
Northern Trust Corp	[2025-06-30]	DFND	258,237	258,319
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	240,873
Renaissance Technologies LLC	[2025-06-30]	SOLE	132,154	132,154
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	115,000	115,000
Millennium Management LLC	[2025-06-30]	SOLE	103,109	103,109
Strategies Wealth Advisors LLC	[2025-06-30]	SOLE	0	100,000
Group One Trading LLC	[2025-06-30]	SOLE	75,899	75,899
683 Capital Management LLC	[2025-06-30]	DFND	62,458	62,458
Marshall Wace LLP	[2025-06-30]	OTR	0	49,991
Creative Planning	[2025-06-30]	SOLE	0	35,000
Vanguard Group Inc	[2025-06-30]	DFND	0	31,867
Citadel Advisors LLC	[2025-06-30]	DFND	31,000	31,000
Bank of New York Mellon Corp	[2025-06-30]	DFND	30,456	30,456
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