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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	4,265,138.0	4,265,138.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	3,655,308.0	3,655,308.0
Deep Track Capital LP	[2023-03-31]	SOLE	3,250,000.0	3,250,000.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	3,214,900.0	3,214,900.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	3,213,586.0
NEA Management Company LLC	[2023-03-31]	DFND	2,437,689.0	2,437,689.0
Sphera Funds Management Ltd	[2023-03-31]	DFND	1,781,858.0	1,781,858.0
Millennium Management LLC	[2023-03-31]	SOLE	1,691,075.0	1,691,075.0
CHI Advisors LLC	[2023-03-31]	DFND	1,342,191.0	1,342,191.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,317,874.0
Citadel Advisors LLC	[2023-03-31]	DFND	822,923.0	822,923.0
Affinity Asset Advisors LLC	[2023-03-31]	SOLE	751,796.0	751,796.0
FMR LLC	[2023-03-31]	DFND	702,996.0	702,996.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	504,407.0	504,407.0
BlackRock Inc.	[2023-03-31]	SOLE	448,213.0	451,193.0
Laurion Capital Management LP	[2023-03-31]	SOLE	271,800.0	271,800.0
Geode Capital Management LLC	[2023-03-31]	DFND	241,208.0	241,208.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	233,728.0	233,728.0
Overbrook Management Corp	[2023-03-31]	SOLE	219,326.0	219,326.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	195,097.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	186,100.0	186,100.0
Knott David M Jr	[2023-03-31]	DFND	160,000.0	160,000.0
UBS OConnor LLC	[2023-03-31]	DFND	147,654.0	147,654.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	125,000.0	125,000.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	117,400.0	117,400.0
State Street Corp	[2023-03-31]	DFND	98,055.0	98,055.0
Two Sigma Investments LP	[2023-03-31]	SOLE	65,500.0	65,500.0
Susquehanna International Group LLP	[2023-03-31]	DFND	0.0	54,000.0
Jane Street Group LLC	[2023-03-31]	DFND	53,525.0	53,525.0
Cubist Systematic Strategies, LLC	[2023-03-31]	DFND	0.0	50,712.0
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