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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vivo Capital LLC	[2025-06-30]	SOLE	6,173,439	6,173,439
Novo Holdings A/S	[2025-06-30]	SOLE	3,354,449	3,354,449
Marshall Wace LLP	[2025-06-30]	OTR	0	2,105,262
PFM Health Sciences LP	[2025-06-30]	DFND	0	1,972,073
Bank of America Corp /DE/	[2025-06-30]	DFND	0	1,615,074
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	864,197
Morgan Stanley	[2025-06-30]	DFND	0	653,678
Dauntless Investment Group, LLC	[2025-06-30]	SOLE	0	324,389
Landscape Capital Management LLC	[2025-06-30]	DFND	286,879	286,879
Soleus Capital Management LP	[2025-06-30]	SOLE	192,670	192,670
Renaissance Technologies LLC	[2025-06-30]	SOLE	139,300	139,300
Sectoral Asset Management Inc	[2025-06-30]	SOLE	91,441	117,691
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	75,000	75,000
Landscape Capital Management LLC	[2025-06-30]	SOLE	60,529	60,529
Marex Group plc	[2025-06-30]	DFND	45,000	45,000
Geode Capital Management LLC	[2025-06-30]	DFND	33,307	33,307
XTX Topco Ltd	[2025-06-30]	DFND	29,189	29,189
Citadel Advisors LLC	[2025-06-30]	DFND	28,866	28,866
Jane Street Group LLC	[2025-06-30]	DFND	25,946	25,946
Newedge Advisors LLC	[2025-06-30]	SOLE	0	24,217
Acadian Asset Management LLC	[2025-06-30]	DFND	23,366	23,366
UBS Group AG	[2025-06-30]	DFND	13,259	13,259
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	13,096
Two Sigma Securities LLC	[2025-06-30]	SOLE	10,385	10,385
Raymond James Financial Inc	[2025-06-30]	DFND	0	1,000
Citigroup Inc	[2025-06-30]	DFND	314	314
SBI Securities Co., Ltd.	[2025-06-30]	DFND	132	132
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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