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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	23,642,636	23,642,990
Vanguard Group Inc	[2025-06-30]	SOLE	0	16,438,969
Capital World Investors	[2025-06-30]	DFND	12,540,188	12,540,188
BlackRock, Inc.	[2025-06-30]	SOLE	10,183,695	10,896,544
Bellevue Group AG	[2025-06-30]	DFND	7,853,198	7,853,198
Wellington Management Group LLP	[2025-06-30]	DFND	0	6,345,776
Deep Track Capital LP	[2025-06-30]	SOLE	4,891,544	4,891,544
State Street Corp	[2025-06-30]	DFND	4,086,741	4,530,398
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	3,800,000	3,800,000
Tweedy, Browne Co LLC	[2025-06-30]	SOLE	2,891,948	2,891,948
Geode Capital Management LLC	[2025-06-30]	DFND	2,891,095	2,891,095
Two Sigma Advisers LP	[2025-06-30]	SOLE	2,562,311	2,667,611
Millennium Management LLC	[2025-06-30]	SOLE	2,649,527	2,649,527
BVF Inc/IL	[2025-06-30]	DFND	0	1,913,385
Two Sigma Investments LP	[2025-06-30]	SOLE	1,788,367	1,788,367
Citadel Advisors LLC	[2025-06-30]	DFND	1,642,281	1,642,281
UBS Group AG	[2025-06-30]	DFND	1,511,548	1,529,323
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,487,818	1,487,818
Macquarie Group Ltd	[2025-06-30]	SOLE	1,434,073	1,434,073
Morgan Stanley	[2025-06-30]	DFND	1,082,395	1,362,209
TD Asset Management Inc	[2025-06-30]	SOLE	1,104,690	1,104,690
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,028,648	1,028,648
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,000,000	1,000,000
Bank of America Corp /DE/	[2025-06-30]	DFND	44,940	995,890
ARK Investment Management LLC	[2025-06-30]	SOLE	900,318	900,318
Voloridge Investment Management LLC	[2025-06-30]	SOLE	854,634	854,634
Northern Trust Corp	[2025-06-30]	DFND	811,972	812,807
Goldman Sachs Group Inc	[2025-06-30]	DFND	745,123	759,578
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	750,000	750,000
Woodline Partners LP	[2025-06-30]	SOLE	732,813	732,813
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