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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	5,410,361	5,410,361
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,100,192
Renaissance Technologies LLC	[2025-06-30]	SOLE	2,022,500	2,022,500
DAFNA Capital Management LLC	[2025-06-30]	SOLE	1,704,232	1,704,232
Casdin Capital LLC	[2025-06-30]	SOLE	1,228,190	1,228,190
Syncona Portfolio Ltd	[2025-06-30]	OTR	0	1,213,056
FMR LLC	[2025-06-30]	DFND	999,723	1,020,614
BlackRock, Inc.	[2025-06-30]	SOLE	916,085	924,683
Tang Capital Management LLC	[2025-06-30]	OTR	0	900,000
Millennium Management LLC	[2025-06-30]	SOLE	812,213	812,213
Two Sigma Investments LP	[2025-06-30]	SOLE	572,544	572,544
GSA Capital Partners LLP	[2025-06-30]	SOLE	466,606	466,606
Superstring Capital Management LP	[2025-06-30]	SOLE	462,963	462,963
Jane Street Group LLC	[2025-06-30]	DFND	444,590	444,590
Geode Capital Management LLC	[2025-06-30]	DFND	380,277	380,277
Two Sigma Advisers LP	[2025-06-30]	SOLE	353,700	367,100
Acadian Asset Management LLC	[2025-06-30]	DFND	307,097	307,097
Goldman Sachs Group Inc	[2025-06-30]	DFND	275,978	275,978
Citadel Advisors LLC	[2025-06-30]	DFND	219,934	219,934
Susquehanna International Group LLP	[2025-06-30]	OTR	199,951	199,951
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	163,377	163,377
AQR Capital Management LLC	[2025-06-30]	DFND	144,162	144,162
Marshall Wace LLP	[2025-06-30]	OTR	0	139,707
State Street Corp	[2025-06-30]	DFND	127,443	127,443
HRT Financial LP	[2025-06-30]	DFND	111,064	111,064
Raymond James Financial Inc	[2025-06-30]	DFND	0	91,323
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	89,975	89,975
Wealth Enhancement Advisory Services LLC	[2025-06-30]	SOLE	24	81,247
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	67,737	67,737
Northern Trust Corp	[2025-06-30]	DFND	67,000	67,000
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