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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	11,189,693	11,189,693
FMR LLC	[2025-06-30]	DFND	8,886,512	8,888,742
Janus Henderson Group PLC	[2025-06-30]	DFND	0	4,460,332
BlackRock, Inc.	[2025-06-30]	SOLE	3,310,522	3,402,847
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	2,920,258	2,920,258
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	2,525,000	2,525,000
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,143,900
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,119,060
Logos Global Management LP	[2025-06-30]	SOLE	1,500,000	1,500,000
Cormorant Asset Management LP	[2025-06-30]	DFND	1,500,000	1,500,000
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,469,818	1,469,818
State Street Corp	[2025-06-30]	DFND	1,299,983	1,388,108
Citadel Advisors LLC	[2025-06-30]	DFND	1,249,526	1,249,526
Woodline Partners LP	[2025-06-30]	SOLE	1,241,938	1,241,938
OrbiMed Advisors LLC	[2025-06-30]	DFND	785,300	1,210,300
Franklin Resources Inc	[2025-06-30]	DFND	1,051,582	1,069,195
Caption Management LLC	[2025-06-30]	SOLE	957,712	957,712
Geode Capital Management LLC	[2025-06-30]	DFND	902,312	902,312
Bank of America Corp /DE/	[2025-06-30]	DFND	5,493	859,423
ProSight Management LP	[2025-06-30]	SOLE	853,904	853,904
Readystate Asset Management LP	[2025-06-30]	SOLE	695,956	695,956
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	595,011	671,485
MPM BioImpact LLC	[2025-06-30]	SOLE	614,282	614,282
Wellington Management Group LLP	[2025-06-30]	DFND	0	492,361
First TURN Management LLC	[2025-06-30]	SOLE	447,420	447,420
Susquehanna International Group LLP	[2025-06-30]	OTR	229,989	395,089
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	[2025-06-30]	SOLE	376,496	376,496
Goldman Sachs Group Inc	[2025-06-30]	DFND	348,450	348,490
Northern Trust Corp	[2025-06-30]	DFND	335,594	335,594
Royal Bank of Canada	[2025-06-30]	DFND	332,146	332,146
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