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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Adar1 Capital Management LLC	[2025-06-30]	SOLE	5,389,264	5,389,264
BlackRock, Inc.	[2025-06-30]	SOLE	2,665,204	2,732,623
Madison Avenue Partners LP	[2025-06-30]	SOLE	2,691,465	2,691,465
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,579,116
Logos Global Management LP	[2025-06-30]	SOLE	2,000,000	2,000,000
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,870,692	1,870,692
Western Standard LLC	[2025-06-30]	SOLE	1,534,893	1,534,893
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,418,984
State Street Corp	[2025-06-30]	DFND	1,341,454	1,384,254
Susquehanna International Group LLP	[2025-06-30]	OTR	113,665	1,306,665
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	1,297,383	1,297,383
OrbiMed Advisors LLC	[2025-06-30]	SOLE	1,018,734	1,018,734
Morgan Stanley	[2025-06-30]	DFND	872,979	878,746
Goldman Sachs Group Inc	[2025-06-30]	DFND	869,898	871,458
Geode Capital Management LLC	[2025-06-30]	DFND	829,297	829,297
Alkeon Capital Management LLC	[2025-06-30]	SOLE	710,064	710,064
Federated Hermes Inc	[2025-06-30]	DFND	654,030	654,030
Redmile Group LLC	[2025-06-30]	SOLE	552,506	552,506
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	412,970	524,340
Janus Henderson Group PLC	[2025-06-30]	DFND	0	472,392
PDT Partners LLC	[2025-06-30]	SOLE	332,815	332,815
Canada Pension Plan Investment Board	[2025-06-30]	SOLE	318,400	318,400
Bank of America Corp /DE/	[2025-06-30]	DFND	16,265	295,477
Rangeley Capital LLC	[2025-06-30]	SOLE	285,400	285,400
Jane Street Group LLC	[2025-06-30]	DFND	170,381	284,281
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	283,403	283,403
Northern Trust Corp	[2025-06-30]	DFND	267,675	267,675
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	265,707	265,707
Newtyn Management LLC	[2025-06-30]	SOLE	246,857	246,857
Deutsche Bank AG	[2025-06-30]	DFND	0	211,637
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