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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	4,333,974	4,334,761
BlackRock, Inc.	[2025-06-30]	SOLE	3,768,505	3,845,008
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,765,685
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	2,660,000	2,660,000
State Street Corp	[2025-06-30]	DFND	1,281,043	1,355,346
Capital World Investors	[2025-06-30]	DFND	942,249	942,249
Soleus Capital Management LP	[2025-06-30]	SOLE	922,958	922,958
Braidwell LP	[2025-06-30]	SOLE	727,811	727,811
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	688,460	688,460
Redmile Group LLC	[2025-06-30]	SOLE	663,471	663,471
Geode Capital Management LLC	[2025-06-30]	DFND	619,547	619,547
Hood River Capital Management LLC	[2025-06-30]	SOLE	516,091	533,023
Goldman Sachs Group Inc	[2025-06-30]	DFND	530,293	530,361
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	449,953	478,471
Susquehanna International Group LLP	[2025-06-30]	OTR	30,252	338,552
Norges Bank	[2025-06-30]	SOLE	282,706	282,706
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	246,162	246,180
Northern Trust Corp	[2025-06-30]	DFND	237,689	238,241
Morgan Stanley	[2025-06-30]	DFND	213,297	234,421
First Trust Advisors LP	[2025-06-30]	SOLE	222,370	222,370
Nantahala Capital Management LLC	[2025-06-30]	SOLE	200,000	200,000
Nuveen, LLC	[2025-06-30]	DFND	188,019	188,019
Bank of New York Mellon Corp	[2025-06-30]	DFND	150,293	160,517
Woodline Partners LP	[2025-06-30]	SOLE	150,616	150,616
UBS Group AG	[2025-06-30]	DFND	149,435	149,440
Segall Bryant & Hamill LLC	[2025-06-30]	SOLE	78,724	148,614
Readystate Asset Management LP	[2025-06-30]	SOLE	147,980	147,980
Principal Financial Group Inc	[2025-06-30]	DFND	140,883	140,883
Caption Management LLC	[2025-06-30]	SOLE	140,000	140,000
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	77,824	135,087
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