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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Eventide Asset Management LLC	[2024-06-30]	SOLE	3,369,147.0	3,369,147.0
Janus Henderson Group PLC	[2024-06-30]	DFND	0.0	3,163,992.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	2,597,736.0	2,597,736.0
Citadel Advisors LLC	[2024-06-30]	DFND	2,558,611.0	2,558,611.0
D1 Capital Partners LP	[2024-06-30]	SOLE	2,506,607.0	2,506,607.0
Omega Fund Management LLC	[2024-06-30]	SOLE	2,355,904.0	2,355,904.0
Novo Holdings A/S	[2024-06-30]	SOLE	1,450,500.0	1,450,500.0
Braidwell LP	[2024-06-30]	SOLE	1,382,481.0	1,382,481.0
Vestal Point Capital LP	[2024-06-30]	SOLE	840,000.0	840,000.0
Woodline Partners LP	[2024-06-30]	SOLE	824,074.0	824,074.0
Blackstone Inc.	[2024-06-30]	OTR	0.0	805,757.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	781,346.0	791,584.0
RA Capital Management LP	[2024-06-30]	SOLE	672,712.0	672,712.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	605,311.0
Artal Group S.A.	[2024-06-30]	DFND	603,435.0	603,435.0
Laurion Capital Management LP	[2024-06-30]	SOLE	453,582.0	453,582.0
Verition Fund Management LLC	[2024-06-30]	SOLE	421,392.0	421,392.0
Geode Capital Management LLC	[2024-06-30]	DFND	296,612.0	296,612.0
State Street Corp	[2024-06-30]	DFND	188,335.0	196,272.0
Tudor Investment Corp ET AL	[2024-06-30]	DFND	132,187.0	132,187.0
Northern Trust Corp	[2024-06-30]	DFND	343.0	94,907.0
Polar Asset Management Partners Inc	[2024-06-30]	SOLE	65,300.0	65,300.0
Millennium Management LLC	[2024-06-30]	SOLE	37,466.0	37,466.0
Bank of New York Mellon Corp	[2024-06-30]	DFND	28,633.0	31,806.0
Charles Schwab Investment Management Inc	[2024-06-30]	SOLE	30,861.0	30,861.0
Goldman Sachs Group Inc	[2024-06-30]	DFND	26,853.0	26,853.0
Jane Street Group LLC	[2024-06-30]	DFND	26,759.0	26,759.0
Vanguard Group Inc	[2024-06-30]	DFND	0.0	24,608.0
Wellington Management Group LLP	[2024-06-30]	DFND	0.0	22,101.0
Barclays PLC	[2024-06-30]	SOLE	19,153.0	19,153.0
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