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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	4,424,725	4,424,725
Balyasny Asset Management LP	[2025-06-30]	SOLE	4,009,137	4,009,137
Janus Henderson Group PLC	[2025-06-30]	DFND	0	3,684,383
Citadel Advisors LLC	[2025-06-30]	DFND	3,607,967	3,607,967
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	3,589,355	3,589,355
Vestal Point Capital LP	[2025-06-30]	SOLE	3,228,161	3,228,161
Millennium Management LLC	[2025-06-30]	SOLE	2,836,292	2,836,292
Woodline Partners LP	[2025-06-30]	SOLE	2,572,162	2,572,162
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,982,869
BlackRock, Inc.	[2025-06-30]	SOLE	1,787,111	1,827,964
Omega Fund Management LLC	[2025-06-30]	SOLE	1,184,636	1,184,636
Blackstone Inc.	[2025-06-30]	OTR	0	1,124,922
D1 Capital Partners LP	[2025-06-30]	SOLE	978,652	978,652
Ally Bridge Group NY LLC	[2025-06-30]	SOLE	867,302	867,302
Point72 Asset Management LP	[2025-06-30]	DFND	0	647,880
Siren, L.L.C.	[2025-06-30]	DFND	603,435	603,435
Geode Capital Management LLC	[2025-06-30]	DFND	578,081	578,081
Ikarian Capital LLC	[2025-06-30]	SOLE	550,029	550,029
State Street Corp	[2025-06-30]	DFND	455,326	513,026
Verition Fund Management LLC	[2025-06-30]	SOLE	414,863	414,863
DAFNA Capital Management LLC	[2025-06-30]	SOLE	378,083	378,083
UBS Group AG	[2025-06-30]	DFND	271,904	271,904
Northern Trust Corp	[2025-06-30]	DFND	197,142	197,142
AQR Capital Management LLC	[2025-06-30]	DFND	185,729	185,729
Privium Fund Management B.V.	[2025-06-30]	SOLE	178,356	178,356
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	163,172
Adar1 Capital Management LLC	[2025-06-30]	SOLE	145,109	145,109
Perceptive Advisors LLC	[2025-06-30]	SOLE	139,835	139,835
Barclays PLC	[2025-06-30]	SOLE	116,142	116,142
Renaissance Technologies LLC	[2025-06-30]	SOLE	106,200	106,200
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