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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
TRV GP IV LLC	[2025-06-30]	SOLE	6,073,958	6,073,958
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	4,567,275	4,567,275
Arch Venture Management LLC	[2025-06-30]	SOLE	0	4,120,053
Deep Track Capital LP	[2025-06-30]	SOLE	3,948,910	3,948,910
Matrix Capital Management Company LP	[2025-06-30]	SOLE	2,486,184	2,486,184
Alphabet Inc.	[2025-06-30]	DFND	0	2,412,471
Foresite Capital Management IV, LLC	[2025-06-30]	SOLE	2,111,919	2,111,919
Ah Capital Management LLC	[2025-06-30]	SOLE	1,702,225	1,702,225
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,401,260
General Catalyst Group Management LLC	[2025-06-30]	DFND	1,035,910	1,035,910
TRV GP V LLC	[2025-06-30]	SOLE	950,800	950,800
Woodline Partners LP	[2025-06-30]	SOLE	940,700	940,700
Casdin Capital LLC	[2025-06-30]	SOLE	758,857	758,857
Harvard Management Co Inc	[2025-06-30]	SOLE	637,528	637,528
BlackRock, Inc.	[2025-06-30]	SOLE	601,539	614,704
Logos Global Management LP	[2025-06-30]	SOLE	611,914	611,914
FMR LLC	[2025-06-30]	DFND	553,897	554,534
HHLR Advisors Ltd	[2025-06-30]	OTR	0	457,535
Vanguard Group Inc	[2025-06-30]	SOLE	0	412,014
Sphera Funds Management Ltd	[2025-06-30]	DFND	356,453	356,453
Foresite Capital Management V, LLC	[2025-06-30]	SOLE	345,191	345,191
Ikarian Capital LLC	[2025-06-30]	SOLE	262,740	262,740
Geode Capital Management LLC	[2025-06-30]	DFND	231,237	231,237
Driehaus Capital Management LLC	[2025-06-30]	SOLE	193,400	193,400
Octagon Capital Advisors LP	[2025-06-30]	SOLE	177,667	177,667
State Street Corp	[2025-06-30]	DFND	132,863	144,685
Alyeska Investment Group LP	[2025-06-30]	SOLE	125,000	125,000
Northern Trust Corp	[2025-06-30]	DFND	84,260	84,260
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	75,530
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	75,171	75,171
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