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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,191,753
Paulson & Co Inc	[2025-06-30]	SOLE	2,089,523	2,089,523
RTW Investments LP	[2025-06-30]	SOLE	1,993,687	1,993,687
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,976,018	1,976,018
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	1,875,000	1,875,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,837,917
BlackRock, Inc.	[2025-06-30]	SOLE	1,400,921	1,438,724
State Street Corp	[2025-06-30]	DFND	642,982	690,715
UBS Group AG	[2025-06-30]	DFND	413,616	505,714
FMR LLC	[2025-06-30]	DFND	444,646	445,339
Geode Capital Management LLC	[2025-06-30]	DFND	414,392	414,392
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	376,163	376,163
Jane Street Group LLC	[2025-06-30]	DFND	49,500	359,600
William Blair Investment Management LLC	[2025-06-30]	SOLE	323,490	350,289
Citadel Advisors LLC	[2025-06-30]	DFND	310,539	310,539
Susquehanna International Group LLP	[2025-06-30]	OTR	100,322	294,422
Armistice Capital LLC	[2025-06-30]	SOLE	294,000	294,000
Bank of America Corp /DE/	[2025-06-30]	DFND	12,237	277,221
Morgan Stanley	[2025-06-30]	DFND	179,129	247,962
Hood River Capital Management LLC	[2025-06-30]	SOLE	237,128	244,738
Polar Capital Holdings Plc	[2025-06-30]	DFND	225,410	225,410
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	188,875	208,266
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	173,133	201,571
Erste Asset Management GmbH	[2025-06-30]	SOLE	201,100	201,100
Invesco Ltd.	[2025-06-30]	DFND	0	200,356
Goldman Sachs Group Inc	[2025-06-30]	DFND	184,391	186,801
683 Capital Management LLC	[2025-06-30]	DFND	176,865	176,865
Norges Bank	[2025-06-30]	SOLE	176,467	176,467
American Century Companies Inc	[2025-06-30]	DFND	139,702	167,784
Woodline Partners LP	[2025-06-30]	SOLE	159,623	159,623
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