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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	1,666,666.0	1,666,666.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,545,113.0	1,545,113.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,383,895.0
BlackRock Inc.	[2023-03-31]	SOLE	937,517.0	952,510.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	650,562.0	650,562.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	531,011.0
State Street Corp	[2023-03-31]	DFND	491,501.0	519,814.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	516,588.0	516,588.0
Susquehanna International Group LLP	[2023-03-31]	DFND	128,958.0	482,258.0
Armistice Capital LLC	[2023-03-31]	SOLE	401,000.0	401,000.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	375,674.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	348,121.0	348,121.0
Citadel Advisors LLC	[2023-03-31]	DFND	277,844.0	277,844.0
FMR LLC	[2023-03-31]	DFND	261,716.0	262,443.0
Geode Capital Management LLC	[2023-03-31]	DFND	248,057.0	248,057.0
Holocene Advisors LP	[2023-03-31]	SOLE	224,600.0	224,600.0
Artisan Partners Limited Partnership	[2023-03-31]	SOLE	169,855.0	215,770.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	178,815.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	150,660.0	175,382.0
Farallon Capital Management LLC	[2023-03-31]	OTR	163,819.0	163,819.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	149,917.0	149,917.0
Morgan Stanley	[2023-03-31]	DFND	96,812.0	147,779.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	142,986.0	142,991.0
Millennium Management LLC	[2023-03-31]	SOLE	120,287.0	137,887.0
Nicholas Investment Partners LP	[2023-03-31]	SOLE	117,047.0	117,047.0
Jane Street Group LLC	[2023-03-31]	DFND	114,563.0	115,192.0
Northern Trust Corp	[2023-03-31]	DFND	4,757.0	113,485.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	106,000.0	106,000.0
EAM Investors LLC	[2023-03-31]	SOLE	46,921.0	100,470.0
Affinity Asset Advisors LLC	[2023-03-31]	SOLE	93,000.0	93,000.0
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