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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Perceptive Advisors LLC	[2025-06-30]	SOLE	12,626,103	12,626,103
Sanofi	[2025-06-30]	SOLE	12,197,737	12,197,737
Johnson & Johnson	[2025-06-30]	DFND	0	6,641,064
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	6,034,578	6,034,578
ProSight Management LP	[2025-06-30]	SOLE	4,587,423	4,587,423
Rubric Capital Management LP	[2025-06-30]	SOLE	3,726,451	3,726,451
BlackRock, Inc.	[2025-06-30]	SOLE	2,799,463	2,862,408
683 Capital Management LLC	[2025-06-30]	DFND	2,690,000	2,690,000
J Goldman & Co LP	[2025-06-30]	SOLE	2,055,274	2,055,274
Knoll Capital Management, LLC	[2025-06-30]	SOLE	1,250,000	1,250,000
Erste Asset Management GmbH	[2025-06-30]	SOLE	789,702	789,702
Millennium Management LLC	[2025-06-30]	SOLE	785,181	785,181
State Street Corp	[2025-06-30]	DFND	625,938	682,202
22NW LP	[2025-06-30]	SOLE	586,519	586,519
Geode Capital Management LLC	[2025-06-30]	DFND	557,569	557,569
Long Focus Capital Management LLC	[2025-06-30]	SOLE	524,745	524,745
Morgan Stanley	[2025-06-30]	DFND	448,916	454,354
Vanguard Group Inc	[2025-06-30]	SOLE	0	386,169
Royal Bank of Canada	[2025-06-30]	DFND	303,871	303,871
Northern Trust Corp	[2025-06-30]	DFND	267,573	267,573
Bank of America Corp /DE/	[2025-06-30]	DFND	10,745	266,666
Citadel Advisors LLC	[2025-06-30]	DFND	241,010	241,010
Wellington Management Group LLP	[2025-06-30]	DFND	0	222,421
Royce & Associates LP	[2025-06-30]	SOLE	217,053	217,053
Platinum Investment Management Ltd	[2025-06-30]	SOLE	208,308	208,308
Privium Fund Management B.V.	[2025-06-30]	SOLE	163,000	163,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	146,493	146,513
Balyasny Asset Management LP	[2025-06-30]	SOLE	140,903	140,903
Nuveen, LLC	[2025-06-30]	DFND	139,145	139,145
Readystate Asset Management LP	[2025-06-30]	SOLE	133,401	133,401
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