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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
NEA Management Company LLC	[2023-03-31]	DFND	4,186,243.0	4,186,243.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	3,860,107.0	3,860,107.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	2,059,201.0	2,059,201.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	2,032,335.0	2,032,335.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	1,795,733.0	1,795,733.0
BlackRock Inc.	[2023-03-31]	SOLE	1,671,312.0	1,709,826.0
Novo Holdings A/S	[2023-03-31]	SOLE	1,684,193.0	1,684,193.0
Rivervest Venture Management LLC	[2023-03-31]	SOLE	1,621,118.0	1,621,118.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,392,945.0	1,392,945.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,224,074.0
State Street Corp	[2023-03-31]	DFND	1,147,254.0	1,170,425.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	1,170,000.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	929,907.0	929,907.0
AXA Sa	[2023-03-31]	DFND	888,554.0	888,554.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	804,129.0
Cadian Capital Management LP	[2023-03-31]	SOLE	734,922.0	734,922.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	601,566.0	601,566.0
ProSight Management LP	[2023-03-31]	SOLE	567,826.0	567,826.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	557,438.0
Woodline Partners LP	[2023-03-31]	SOLE	523,880.0	523,880.0
Geode Capital Management LLC	[2023-03-31]	DFND	418,214.0	418,214.0
Franklin Resources Inc	[2023-03-31]	DFND	400,502.0	400,502.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	392,352.0	392,372.0
Barclays PLC	[2023-03-31]	SOLE	299,463.0	299,463.0
Soleus Capital Management LP	[2023-03-31]	SOLE	242,000.0	242,000.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	225,700.0	225,700.0
Northern Trust Corp	[2023-03-31]	DFND	8,619.0	214,197.0
Silvercrest Asset Management Group LLC	[2023-03-31]	SOLE	109,733.0	201,380.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	154,750.0
Highlander Partners, L.P.	[2023-03-31]	SOLE	122,980.0	122,980.0
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