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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	6,795,121	6,795,121
Janus Henderson Group PLC	[2025-06-30]	DFND	0	5,236,277
BlackRock, Inc.	[2025-06-30]	SOLE	3,474,690	3,577,091
BVF Inc/IL	[2025-06-30]	DFND	0	2,761,333
Eventide Asset Management LLC	[2025-06-30]	SOLE	2,637,485	2,637,485
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,473,843
Novo Holdings A/S	[2025-06-30]	SOLE	1,500,055	1,500,055
Citadel Advisors LLC	[2025-06-30]	DFND	1,433,152	1,433,152
State Street Corp	[2025-06-30]	DFND	1,296,755	1,375,628
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,236,027
Geode Capital Management LLC	[2025-06-30]	DFND	1,029,616	1,029,616
Clearbridge Investments LLC	[2025-06-30]	SOLE	1,018,159	1,027,527
Polar Capital Holdings Plc	[2025-06-30]	DFND	975,000	975,000
Rock Springs Capital Management LP	[2025-06-30]	SOLE	818,206	818,206
Lord Abbett & Co LLC	[2025-06-30]	SOLE	570,788	755,707
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	632,022	701,156
Boone Capital Management LLC	[2025-06-30]	SOLE	641,448	641,448
Franklin Resources Inc	[2025-06-30]	DFND	593,450	593,596
Nuveen, LLC	[2025-06-30]	DFND	585,245	590,257
Woodline Partners LP	[2025-06-30]	SOLE	567,894	567,894
Morgan Stanley	[2025-06-30]	DFND	559,319	566,326
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	539,357	554,957
Loomis Sayles & Co L P	[2025-06-30]	DFND	543,225	552,957
First TURN Management LLC	[2025-06-30]	SOLE	527,540	527,540
Bank of New York Mellon Corp	[2025-06-30]	DFND	459,703	496,061
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	481,464
JPMorgan Chase & Co	[2025-06-30]	DFND	427,837	479,707
Macquarie Group Ltd	[2025-06-30]	SOLE	435,717	435,717
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	423,744	423,744
Renaissance Technologies LLC	[2025-06-30]	SOLE	396,348	396,348
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