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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	19,751,284
Cormorant Asset Management LP	[2025-06-30]	DFND	8,494,151	8,494,151
FMR LLC	[2025-06-30]	DFND	5,728,477	5,730,549
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	4,150,000	4,150,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,719,541	1,719,541
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,275,569	1,275,569
Westfield Capital Management Co LP	[2025-06-30]	SOLE	934,499	1,259,376
Federated Hermes Inc	[2025-06-30]	DFND	1,236,383	1,248,573
AllianceBernstein LP	[2025-06-30]	DFND	1,066,382	1,138,022
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	878,323	878,323
Nuveen, LLC	[2025-06-30]	DFND	791,555	791,555
RTW Investments LP	[2025-06-30]	SOLE	741,090	741,090
Hood River Capital Management LLC	[2025-06-30]	SOLE	653,954	675,445
Vestal Point Capital LP	[2025-06-30]	SOLE	550,000	550,000
Caption Management LLC	[2025-06-30]	SOLE	530,369	530,369
Marshall Wace LLP	[2025-06-30]	OTR	0	529,211
Siren, L.L.C.	[2025-06-30]	DFND	508,267	508,267
Balyasny Asset Management LP	[2025-06-30]	SOLE	423,170	423,170
BlackRock, Inc.	[2025-06-30]	SOLE	295,892	327,342
MPM BioImpact LLC	[2025-06-30]	SOLE	313,571	313,571
Woodline Partners LP	[2025-06-30]	SOLE	310,602	310,602
Fred Alger Management LLC	[2025-06-30]	SOLE	295,623	295,623
Saturn V Capital Management LP	[2025-06-30]	SOLE	290,784	290,784
Ikarian Capital LLC	[2025-06-30]	SOLE	289,000	289,000
5AM Venture Management LLC	[2025-06-30]	SOLE	282,313	282,313
Polar Capital Holdings Plc	[2025-06-30]	DFND	247,500	247,500
Voya Investment Management LLC	[2025-06-30]	DFND	0	246,114
Susquehanna International Group LLP	[2025-06-30]	OTR	0	213,400
Ameriprise Financial Inc	[2025-06-30]	DFND	0	200,321
Integral Health Asset Management LLC	[2025-06-30]	SOLE	200,000	200,000
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