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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2024-06-30]	DFND	0.0	21,751,284.0
Cormorant Asset Management LP	[2024-06-30]	DFND	8,494,151.0	8,494,151.0
FMR LLC	[2024-06-30]	DFND	3,641,559.0	3,644,009.0
Avoro Capital Advisors LLC	[2024-06-30]	SOLE	2,770,000.0	2,770,000.0
Price T Rowe Associates Inc /MD/	[2024-06-30]	SOLE	2,531,759.0	2,561,512.0
Citadel Advisors LLC	[2024-06-30]	DFND	2,297,495.0	2,297,495.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	1,825,000.0	1,825,000.0
Holocene Advisors LP	[2024-06-30]	SOLE	1,626,341.0	1,626,341.0
Logos Global Management LP	[2024-06-30]	SOLE	1,500,000.0	1,500,000.0
Goldman Sachs Group Inc	[2024-06-30]	DFND	1,251,020.0	1,251,747.0
Federated Hermes Inc	[2024-06-30]	DFND	1,110,438.0	1,128,428.0
Westfield Capital Management Co LP	[2024-06-30]	SOLE	945,301.0	1,117,625.0
Marshall Wace LLP	[2024-06-30]	OTR	0.0	1,098,630.0
AllianceBernstein LP	[2024-06-30]	DFND	947,308.0	1,021,750.0
Polar Capital Holdings Plc	[2024-06-30]	DFND	678,169.0	678,169.0
Fred Alger Management LLC	[2024-06-30]	SOLE	659,029.0	659,029.0
Balyasny Asset Management LP	[2024-06-30]	SOLE	584,263.0	584,263.0
Nuveen Asset Management LLC	[2024-06-30]	DFND	521,713.0	521,713.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	359,607.0	392,024.0
Finepoint Capital LP	[2024-06-30]	SOLE	388,835.0	388,835.0
Wellington Management Group LLP	[2024-06-30]	DFND	0.0	372,657.0
Camber Capital Management LP	[2024-06-30]	SOLE	355,000.0	355,000.0
Pictet Asset Management Holding SA	[2024-06-30]	SOLE	307,334.0	345,840.0
MPM BioImpact LLC	[2024-06-30]	SOLE	343,235.0	343,235.0
Ghost Tree Capital LLC	[2024-06-30]	SOLE	300,000.0	300,000.0
Granahan Investment Management LLC	[2024-06-30]	SOLE	213,685.0	283,649.0
5AM Venture Management LLC	[2024-06-30]	SOLE	282,313.0	282,313.0
Candriam S.C.A.	[2024-06-30]	SOLE	239,000.0	239,000.0
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	[2024-06-30]	SOLE	228,803.0	228,803.0
Woodline Partners LP	[2024-06-30]	SOLE	226,717.0	226,717.0
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