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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Inc.	[2023-03-31]	SOLE	20,160,064.0	20,683,351.0
State Street Corp	[2023-03-31]	DFND	17,482,612.0	17,887,348.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	13,565,360.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	9,100,000.0	9,100,000.0
FMR LLC	[2023-03-31]	DFND	6,451,540.0	6,456,855.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	5,809,358.0	5,810,053.0
Geode Capital Management LLC	[2023-03-31]	DFND	5,157,086.0	5,157,086.0
Millennium Management LLC	[2023-03-31]	SOLE	3,984,682.0	3,984,682.0
Emerald Advisers LLC	[2023-03-31]	SOLE	2,653,801.0	3,635,209.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	3,574,020.0	3,574,020.0
Two Sigma Investments LP	[2023-03-31]	SOLE	3,071,455.0	3,071,455.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,939,449.0	2,939,449.0
Bank of America Corp /DE/	[2023-03-31]	DFND	75,353.0	2,838,103.0
Northern Trust Corp	[2023-03-31]	DFND	130,438.0	2,389,541.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	1,894,230.0	2,048,427.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	1,930,382.0	1,930,382.0
Emerald Mutual Fund Advisers Trust	[2023-03-31]	SOLE	1,879,671.0	1,879,671.0
Woodline Partners LP	[2023-03-31]	SOLE	1,834,280.0	1,834,280.0
Lazard Asset Management LLC	[2023-03-31]	SOLE	1,706,717.0	1,715,013.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,598,379.0	1,598,519.0
180 Wealth Advisors LLC	[2023-03-31]	SOLE	0.0	1,482,638.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	1,474,098.0	1,474,098.0
Rafferty Asset Management LLC	[2023-03-31]	SOLE	1,382,870.0	1,382,870.0
Morgan Stanley	[2023-03-31]	DFND	843,696.0	1,307,320.0
Susquehanna International Group LLP	[2023-03-31]	DFND	866,811.0	1,186,411.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	1,171,345.0	1,171,345.0
Citigroup Inc	[2023-03-31]	DFND	1,108,586.0	1,108,586.0
Apollo Management Holdings, L.P.	[2023-03-31]	DFND	0.0	964,113.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	714,506.0	861,052.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	847,014.0	847,014.0
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