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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	5,645,334	5,802,139
Commodore Capital LP	[2025-06-30]	SOLE	5,000,000	5,000,000
Blackstone Inc.	[2025-06-30]	OTR	0	3,587,479
Marshall Wace LLP	[2025-06-30]	OTR	0	3,421,224
Driehaus Capital Management LLC	[2025-06-30]	SOLE	2,708,586	3,092,658
Deep Track Capital LP	[2025-06-30]	SOLE	2,500,000	2,500,000
Octagon Capital Advisors LP	[2025-06-30]	SOLE	2,130,000	2,130,000
State Street Corp	[2025-06-30]	DFND	1,687,571	1,805,893
Geode Capital Management LLC	[2025-06-30]	DFND	1,733,454	1,733,454
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,687,487
AWM Investment Company Inc	[2025-06-30]	SOLE	1,215,662	1,215,662
Ally Bridge Group NY LLC	[2025-06-30]	SOLE	726,172	726,172
Morgan Stanley	[2025-06-30]	DFND	642,972	688,531
Susquehanna International Group LLP	[2025-06-30]	OTR	169,325	637,425
Tang Capital Management LLC	[2025-06-30]	OTR	0	600,200
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	598,212	598,212
Northern Trust Corp	[2025-06-30]	DFND	587,688	587,688
UBS Group AG	[2025-06-30]	DFND	513,305	514,445
Woodline Partners LP	[2025-06-30]	SOLE	502,198	502,198
Citadel Advisors LLC	[2025-06-30]	DFND	451,704	451,704
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	420,000	420,000
Wellington Management Group LLP	[2025-06-30]	DFND	0	261,953
Bank of New York Mellon Corp	[2025-06-30]	DFND	224,789	240,739
Nuveen, LLC	[2025-06-30]	DFND	239,842	239,842
Millennium Management LLC	[2025-06-30]	SOLE	183,400	183,400
Barclays PLC	[2025-06-30]	SOLE	175,233	175,233
Jane Street Group LLC	[2025-06-30]	DFND	128,315	161,515
Diadema Partners LP	[2025-06-30]	SOLE	158,536	158,536
Crawford Fund Management LLC	[2025-06-30]	OTR	0	132,500
Vanguard Group Inc	[2025-06-30]	DFND	0	126,509
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