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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,172,368
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	599,195	599,195
RA Capital Management LP	[2025-06-30]	SOLE	511,207	511,207
BlackRock, Inc.	[2025-06-30]	SOLE	201,654	205,169
Point72 Asset Management LP	[2025-06-30]	DFND	0	104,019
Adar1 Capital Management LLC	[2025-06-30]	SOLE	100,974	100,974
Geode Capital Management LLC	[2025-06-30]	DFND	96,919	96,919
Vanguard Group Inc	[2025-06-30]	SOLE	0	80,976
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	67,500	67,500
State Street Corp	[2025-06-30]	DFND	37,745	41,826
Ally Bridge Group NY LLC	[2025-06-30]	SOLE	34,537	34,537
Northern Trust Corp	[2025-06-30]	DFND	31,189	31,189
UBS Group AG	[2025-06-30]	DFND	21,873	21,873
Millennium Management LLC	[2025-06-30]	SOLE	14,789	14,789
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	13,249	13,249
Bank of New York Mellon Corp	[2025-06-30]	DFND	8,792	8,948
Susquehanna International Group LLP	[2025-06-30]	OTR	8,356	8,356
Morgan Stanley	[2025-06-30]	DFND	7,832	7,932
Barclays PLC	[2025-06-30]	SOLE	7,285	7,285
Citadel Advisors LLC	[2025-06-30]	DFND	6,232	6,232
RhumbLine Advisers	[2025-06-30]	SOLE	1,721	5,850
Gerber LLC	[2025-06-30]	SOLE	0	5,601
Vanguard Group Inc	[2025-06-30]	DFND	0	5,513
Deutsche Bank AG	[2025-06-30]	DFND	97	3,385
New York State Common Retirement Fund	[2025-06-30]	SOLE	2,900	2,900
MetLife Investment Management LLC	[2025-06-30]	DFND	2,538	2,538
Wells Fargo & Company/MN	[2025-06-30]	DFND	2,101	2,301
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	[2025-06-30]	DFND	2,222	2,222
Bank of America Corp /DE/	[2025-06-30]	DFND	750	2,109
JPMorgan Chase & Co	[2025-06-30]	DFND	0	1,921
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