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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Ah Capital Management LLC	[2025-06-30]	SOLE	17,653,917	17,653,917
Perceptive Advisors LLC	[2025-06-30]	SOLE	12,594,211	12,594,211
Cercano Management LLC	[2025-06-30]	SOLE	7,172,985	7,172,985
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,468,474
Comprehensive Financial Management LLC	[2025-06-30]	SOLE	2,207,619	2,207,619
Amazon Com Inc	[2025-06-30]	SOLE	1,457,055	1,457,055
Clarius Group, LLC	[2025-06-30]	SOLE	558,851	1,060,460
Millennium Management LLC	[2025-06-30]	SOLE	1,056,839	1,056,839
Tikvah Management LLC	[2025-06-30]	SOLE	726,895	726,895
BlackRock, Inc.	[2025-06-30]	SOLE	619,892	628,901
ArchPoint Investors	[2025-06-30]	SOLE	622,409	622,409
Renaissance Technologies LLC	[2025-06-30]	SOLE	619,906	619,906
Geode Capital Management LLC	[2025-06-30]	DFND	553,602	553,602
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	446,894	446,894
Corient Private Wealth LLC	[2025-06-30]	SOLE	45,349	435,350
Citadel Advisors LLC	[2025-06-30]	DFND	336,355	336,355
Goldman Sachs Group Inc	[2025-06-30]	DFND	314,938	314,938
Jane Street Group LLC	[2025-06-30]	DFND	290,369	290,369
Sentinel Trust Co LBA	[2025-06-30]	SOLE	280,000	280,000
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	254,859	254,859
Alyeska Investment Group LP	[2025-06-30]	SOLE	253,468	253,468
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	224,456	224,456
Hillman Co	[2025-06-30]	SOLE	200,000	200,000
State Street Corp	[2025-06-30]	DFND	181,616	181,616
GSA Capital Partners LLP	[2025-06-30]	SOLE	176,908	176,908
Northern Trust Corp	[2025-06-30]	DFND	148,467	148,467
Susquehanna International Group LLP	[2025-06-30]	OTR	147,497	147,497
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	125,000	125,000
Dimensional Fund Advisors LP	[2025-06-30]	DFND	0	103,846
Squarepoint Ops LLC	[2025-06-30]	DFND	0	101,822
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