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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	16,716,661	16,722,755
BlackRock, Inc.	[2025-06-30]	SOLE	13,245,767	14,114,484
Vanguard Group Inc	[2025-06-30]	SOLE	0	10,504,667
Soleus Capital Management LP	[2025-06-30]	SOLE	6,904,302	6,904,302
Capital World Investors	[2025-06-30]	DFND	6,382,848	6,382,848
State Street Corp	[2025-06-30]	DFND	2,315,142	2,678,072
Geode Capital Management LLC	[2025-06-30]	DFND	2,444,436	2,444,436
Balyasny Asset Management LP	[2025-06-30]	SOLE	2,270,076	2,270,076
Marshall Wace LLP	[2025-06-30]	OTR	0	1,414,599
Quantinno Capital Management LP	[2025-06-30]	SOLE	1,368,663	1,368,663
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,300,054	1,300,054
Citadel Advisors LLC	[2025-06-30]	DFND	1,110,348	1,110,348
Northern Trust Corp	[2025-06-30]	DFND	1,075,795	1,080,342
American Century Companies Inc	[2025-06-30]	DFND	1,029,874	1,029,874
Nuveen, LLC	[2025-06-30]	DFND	1,018,231	1,026,438
Palo Alto Investors LP	[2025-06-30]	SOLE	962,396	962,396
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	910,323	910,323
Deerfield Management Company LP	[2025-06-30]	DFND	825,119	825,119
Goldman Sachs Group Inc	[2025-06-30]	DFND	750,271	750,516
Voloridge Investment Management LLC	[2025-06-30]	SOLE	746,935	746,935
Morgan Stanley	[2025-06-30]	DFND	677,089	731,629
Citigroup Inc	[2025-06-30]	DFND	705,646	705,646
Frontier Capital Management Co LLC	[2025-06-30]	SOLE	355,173	705,538
Baillie Gifford & Co	[2025-06-30]	DFND	668,041	668,041
Susquehanna International Group LLP	[2025-06-30]	OTR	287,771	665,871
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	563,487	647,666
Millennium Management LLC	[2025-06-30]	SOLE	646,780	646,780
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	645,183
C WorldWide Group Holding A/S	[2025-06-30]	DFND	621,784	621,784
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	610,714	610,714
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