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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	4,500,386.0	4,500,897.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	4,272,563.0
BlackRock Inc.	[2023-03-31]	SOLE	3,101,377.0	3,181,895.0
Braidwell LP	[2023-03-31]	SOLE	1,632,915.0	1,632,915.0
ArrowMark Colorado Holdings LLC	[2023-03-31]	SOLE	1,331,756.0	1,331,756.0
Fred Alger Management LLC	[2023-03-31]	SOLE	894,617.0	1,174,243.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	1,077,900.0	1,077,900.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	1,050,809.0
State Street Corp	[2023-03-31]	DFND	844,021.0	922,438.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	798,326.0	802,595.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	705,357.0	705,357.0
Geode Capital Management LLC	[2023-03-31]	DFND	658,713.0	658,713.0
Principal Financial Group Inc	[2023-03-31]	DFND	649,956.0	649,956.0
Millennium Management LLC	[2023-03-31]	SOLE	638,974.0	638,974.0
Federated Hermes Inc	[2023-03-31]	DFND	558,972.0	559,018.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	483,700.0	535,600.0
Two Sigma Investments LP	[2023-03-31]	SOLE	486,617.0	486,617.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	436,498.0	436,498.0
Citadel Advisors LLC	[2023-03-31]	DFND	432,290.0	432,290.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	431,900.0	431,900.0
Morgan Stanley	[2023-03-31]	DFND	390,487.0	418,679.0
Franklin Resources Inc	[2023-03-31]	DFND	384,698.0	384,698.0
Woodline Partners LP	[2023-03-31]	SOLE	368,606.0	368,606.0
Credit Suisse AG	[2023-03-31]	DFND	332,883.0	350,215.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	344,774.0	349,080.0
Northern Trust Corp	[2023-03-31]	DFND	19,806.0	335,927.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	60,689.0	319,859.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	211,016.0	281,875.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	262,591.0	262,591.0
Voloridge Investment Management LLC	[2023-03-31]	SOLE	235,311.0	235,311.0
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