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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vestal Point Capital LP	[2025-06-30]	SOLE	1,402,002	1,402,002
BlackRock, Inc.	[2025-06-30]	SOLE	711,014	779,690
FMR LLC	[2025-06-30]	DFND	679,586	679,586
Franklin Resources Inc	[2025-06-30]	DFND	294,990	294,990
Rossmore Private Capital	[2025-06-30]	SOLE	117,940	117,940
Millennium Management LLC	[2025-06-30]	SOLE	115,026	115,026
AXA Sa	[2025-06-30]	DFND	86,142	86,142
Kovack Advisors Inc	[2025-06-30]	SOLE	0	57,827
SIO Capital Management LLC	[2025-06-30]	SOLE	50,839	50,839
Ikarian Capital LLC	[2025-06-30]	SOLE	50,627	50,627
Shay Capital LLC	[2025-06-30]	SOLE	50,000	50,000
LPL Financial LLC	[2025-06-30]	SOLE	0	35,391
Federation des caisses Desjardins du Quebec	[2025-06-30]	DFND	30,900	30,900
DekaBank Deutsche Girozentrale	[2025-06-30]	DFND	26,200	26,200
Geode Capital Management LLC	[2025-06-30]	DFND	17,170	17,170
Walleye Capital LLC	[2025-06-30]	SOLE	15,681	15,681
Goldman Sachs Group Inc	[2025-06-30]	DFND	15,508	15,508
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	14,743
Balyasny Asset Management LP	[2025-06-30]	SOLE	11,281	11,281
Raymond James Financial Inc	[2025-06-30]	DFND	0	9,409
Bank of America Corp /DE/	[2025-06-30]	DFND	1,800	7,866
Barclays PLC	[2025-06-30]	SOLE	3,943	3,943
GHP Investment Advisors Inc	[2025-06-30]	SOLE	0	2,590
Morgan Stanley	[2025-06-30]	DFND	0	2,475
Larson Financial Group LLC	[2025-06-30]	SOLE	0	744
UBS Group AG	[2025-06-30]	DFND	691	691
Fourth Dimension Wealth LLC	[2025-06-30]	SOLE	0	390
Cheviot Value Management LLC	[2025-06-30]	SOLE	200	200
SBI Securities Co., Ltd.	[2025-06-30]	DFND	3	3
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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