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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Summer Road LLC	[2023-03-31]	DFND	6,122,089.0	6,122,089.0
Opaleye Management Inc	[2023-03-31]	SOLE	6,105,900.0	6,105,900.0
BlackRock Inc.	[2023-03-31]	SOLE	4,884,541.0	4,918,309.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,895,751.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,975,072.0	1,975,072.0
Deltec Asset Management LLC	[2023-03-31]	SOLE	1,913,612.0	1,913,612.0
State Street Corp	[2023-03-31]	DFND	1,413,595.0	1,492,959.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,457,740.0	1,457,740.0
Morgan Stanley	[2023-03-31]	DFND	1,071,739.0	1,181,703.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	1,099,770.0	1,099,770.0
Millennium Management LLC	[2023-03-31]	SOLE	1,036,555.0	1,036,555.0
Susquehanna International Group LLP	[2023-03-31]	DFND	244,579.0	713,179.0
Northern Trust Corp	[2023-03-31]	DFND	31,768.0	657,097.0
Cetera Investment Advisers	[2023-03-31]	SOLE	0.0	601,150.0
Endurant Capital Management LP	[2023-03-31]	SOLE	512,744.0	512,744.0
UBS OConnor LLC	[2023-03-31]	DFND	363,286.0	363,286.0
Two Sigma Investments LP	[2023-03-31]	SOLE	323,424.0	323,424.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	243,100.0	309,400.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	307,108.0
Knoll Capital Management, LLC	[2023-03-31]	SOLE	295,800.0	295,800.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	260,699.0	290,055.0
Barclays PLC	[2023-03-31]	SOLE	279,687.0	279,687.0
Banco Santander, S.A.	[2023-03-31]	DFND	267,889.0	267,889.0
Levin Capital Strategies LP	[2023-03-31]	OTR	0.0	207,624.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	206,249.0	206,249.0
Ikarian Capital LLC	[2023-03-31]	SOLE	200,000.0	200,000.0
Nottingham Advisors Inc	[2023-03-31]	SOLE	0.0	194,266.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	193,033.0	193,033.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	180,605.0	180,665.0
Royal Bank of Canada	[2023-03-31]	DFND	180,001.0	180,001.0
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