Opaleye Management Inc

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Opaleye Management Inc
CRD #124513
SEC #801-78700
CIK #0001595855
AUM 802.8 M (2026-02-19)
Employees 4 (100% Investors, 0% Brokers)
Phone617-229-5085
AddressOne Boston Place
Boston, MA 02108
Source [IAPD] [EDGAR]
Total AUM ($M)
90072054036018002010201520212027
Sector Form 13F Holdings Value ($M)
Transdel Pharmaceuticals Inc 99.9
Liquidia Corp 88.8
Eton Pharmaceuticals Inc 70.6
Sol-Gel Technologies Ltd 39.6
Apogee Therapeutics Inc 32.8
FS Development Corp 26.9
UroGen Pharma Ltd 25.7
Glycomimetics Inc 24.1
Stoke Therapeutics Inc 22.8
Isoray Inc 19.5
View All
Holdings by Sector ($M)
80064048032016002013201720222027
Type Form D Funds Date Sold AUM
HF Opaleye LP [2013-10-09] 42.3 M 789.2 M
Filed 2017-06-07 (D/A) · Exemption 506(b), 3(c), 3(c)(1) · Minimum $50,000 · Remaining Indefinite · Duration More than one year · Net Assets Decline to Disclose
AUM Breakdown Accounts AUM ($M)
By Client Type
(a) Individuals (other than high net worth individuals) 0 0.0
(b) Individuals (high net worth individuals) 0 0.0
(c) Banking or thrift institutions 0 0.0
(d) Investment companies 0 0.0
(e) Business development companies 0 0.0
(f) Pooled investment vehicles 1 789.2
(g) Pension and profit sharing plans 0 0.0
(h) Charitable organizations 0 0.0
(i) State or municipal government entities 0 0.0
(j) Other investment advisers 0 0.0
(k) Insurance companies 0 0.0
(l) Sovereign wealth funds and foreign official institutions 0 0.0
(m) Corporations or other businesses not listed above 1 13.6
(n) Other 0 0.0
Total 2 802.8
By Discretionary
Discretionary 2 802.8
Non-Discretionary 0 0.0
Total 2 802.8
By Non-United States Persons
Non-United States Persons 13.6
United States Persons 789.2
Total 2 802.8
Form D Directors Role # Filings # Firms 2011 - 2026
James Silverman Executive Officer 3 2
Rrc Management LLC Executive Officer 1 1
Opaleye Management Inc Promoter 1 1
Opaleye GP LLC Promoter 1 1
EDGAR Form CIK 2011 - 2026
13F-HR [0001595855]
3 [0001595855]
4 [0001595855]
SC 13D [0001595855]
SC 13G [0001595855]
Form 13D/13G Filer Form 13D/13G Subject Filed
Opaleye Management Inc Pasithea Therapeutics Corp [2026-04-08]
Opaleye Management Inc Q32 Bio Inc [2026-02-20]
Opaleye Management Inc Alpha Cognition Inc [2026-02-06]
Opaleye Management Inc Rezolute Inc [2025-12-19]
Opaleye Management Inc Karyopharm Therapeutics Inc [2025-10-17]
Opaleye Management Inc Alpha Cognition Inc [2025-10-03]
Opaleye Management Inc Larimar Therapeutics Inc [2025-04-16]
Opaleye Management Inc Protara Therapeutics Inc [2024-11-18]
Opaleye Management Inc Codexis Inc [2024-07-12]
Opaleye Management Inc IBIO Inc [2024-04-08]
View All
Firm Profile (Form ADV)
Discretionary AUM$0.2B
ServesInstitutional
Fund TypesHedge Fund
Form 3/4/5 Subject 2011 - 2026
Opaleye Management Inc
Eton Pharmaceuticals Inc
Sol-Gel Technologies Ltd
Alpha Cognition Inc
SANUWAVE Health Inc
Harrow Inc
Codexis Inc
Proteon Therapeutics Inc
Tracon Pharmaceuticals Inc
TELA Bio Inc
View All
Insider Transaction (Form 3/4/5) Date Action Shares Price Value ($)
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-30 Buy 1,850 $4.99 9,232
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-27 Buy 10,000 $5.08 50,800
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-26 Buy 7,319 $5.28 38,644
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-25 Buy 8,581 $5.43 46,595
Sol-Gel Technologies Ltd SLGL
Ordinary Shares, par value NIS 1.00 per share.
2026-03-24 Buy 34,665 $72.00 2,495,880
Sol-Gel Technologies Ltd SLGL
Ordinary Shares, par value NIS 1.00 per share.
2026-03-24 Buy 5,000 $72.00 360,000
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-24 Buy 4,182 $5.59 23,377
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-19 Buy 2,094 $5.71 11,957
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-18 Buy 2,481 $5.75 14,266
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-16 Buy 1,331 $5.78 7,693
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-13 Buy 7,358 $5.75 42,308
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-12 Buy 5,708 $5.85 33,392
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-09 Buy 2,179 $5.85 12,747
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-06 Buy 1,900 $5.80 11,020
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-05 Buy 42,023 $5.80 243,733
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-05 Buy 5,000 $5.80 29,000
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-04 Buy 19,795 $5.81 115,009
Harrow Inc HROW
Common Stock, par value $0.001 per share
2026-03-04 Sell 134,000 $39.67 5,315,780
Harrow Inc HROW
Common Stock, par value $0.001 per share
2026-03-04 Sell 4,263 $39.67 169,113
Alpha Cognition Inc ACOG
Common Stock, no par value
2026-03-03 Buy 46,411 $5.75 266,863
showing 20 of 200 most recent transactions
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