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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2023-03-31]	DFND	0.0	7,611,503.0
Logos Global Management LP	[2023-03-31]	SOLE	3,743,875.0	3,743,875.0
Cormorant Asset Management LP	[2023-03-31]	DFND	3,082,000.0	3,082,000.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	2,382,377.0	2,382,377.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	2,085,179.0
Kynam Capital Management LP	[2023-03-31]	SOLE	2,011,853.0	2,011,853.0
Vivo Capital LLC	[2023-03-31]	SOLE	1,689,515.0	1,689,515.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,497,615.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,231,116.0	1,231,116.0
BlackRock Inc.	[2023-03-31]	SOLE	948,119.0	996,177.0
Sectoral Asset Management Inc	[2023-03-31]	SOLE	371,917.0	995,909.0
Acadian Asset Management LLC	[2023-03-31]	DFND	575,900.0	575,900.0
Laurion Capital Management LP	[2023-03-31]	SOLE	513,972.0	513,972.0
J Goldman & Co LP	[2023-03-31]	SOLE	447,083.0	447,083.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	420,000.0	420,000.0
Newtyn Management LLC	[2023-03-31]	SOLE	375,000.0	375,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	349,946.0	349,946.0
Vontobel Holding Ltd.	[2023-03-31]	DFND	337,917.0	337,917.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	257,200.0	257,200.0
Deutsche Bank AG	[2023-03-31]	DFND	22,040.0	254,718.0
GSA Capital Partners LLP	[2023-03-31]	SOLE	230,632.0	230,632.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	230,568.0	230,568.0
Monaco Asset Management SAM	[2023-03-31]	SOLE	221,905.0	221,905.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	186,000.0	205,900.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	191,215.0	192,215.0
Walleye Capital LLC	[2023-03-31]	SOLE	182,337.0	182,337.0
Two Sigma Investments LP	[2023-03-31]	SOLE	161,433.0	161,433.0
State Street Corp	[2023-03-31]	DFND	121,181.0	121,181.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	115,687.0	115,687.0
Morgan Stanley	[2023-03-31]	DFND	113,740.0	113,890.0
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