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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	6,843,954	6,843,954
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	6,764,172	6,764,172
BVF Inc/IL	[2025-06-30]	DFND	0	5,295,893
BlackRock, Inc.	[2025-06-30]	SOLE	4,481,778	4,605,109
Woodline Partners LP	[2025-06-30]	SOLE	3,505,893	3,505,893
Deep Track Capital LP	[2025-06-30]	SOLE	3,442,833	3,442,833
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,228,009
Logos Global Management LP	[2025-06-30]	SOLE	3,208,875	3,208,875
Janus Henderson Group PLC	[2025-06-30]	DFND	0	3,022,784
Franklin Resources Inc	[2025-06-30]	DFND	3,011,969	3,011,969
MPM BioImpact LLC	[2025-06-30]	SOLE	2,378,762	2,378,762
Lightspeed Management Company LLC	[2025-06-30]	SOLE	1,930,894	1,930,894
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,747,813	1,879,013
Citadel Advisors LLC	[2025-06-30]	DFND	1,739,534	1,739,534
Vivo Capital LLC	[2025-06-30]	SOLE	1,505,862	1,505,862
Morgan Stanley	[2025-06-30]	DFND	1,429,668	1,437,407
UBS Group AG	[2025-06-30]	DFND	1,412,099	1,412,099
Geode Capital Management LLC	[2025-06-30]	DFND	1,326,123	1,326,123
Millennium Management LLC	[2025-06-30]	SOLE	1,271,090	1,271,090
Ameriprise Financial Inc	[2025-06-30]	DFND	0	1,172,863
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,052,090	1,112,139
State Street Corp	[2025-06-30]	DFND	983,267	1,051,967
Candriam S.C.A.	[2025-06-30]	SOLE	850,454	850,454
Bank of America Corp /DE/	[2025-06-30]	DFND	7,571	799,502
Pier Capital LLC	[2025-06-30]	SOLE	478,243	771,072
Goldman Sachs Group Inc	[2025-06-30]	DFND	724,297	724,582
Schroder Investment Management Group	[2025-06-30]	SOLE	618,184	618,184
Northern Trust Corp	[2025-06-30]	DFND	489,493	490,316
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	430,522	430,522
	[2025-06-30]	SOLE	278,430	278,430
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