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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	4,005,487.0	4,007,099.0
Column Group LLC	[2023-03-31]	SOLE	3,568,181.0	3,568,181.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	3,418,068.0	3,418,068.0
Millennium Management LLC	[2023-03-31]	SOLE	2,267,642.0	2,267,642.0
Alkeon Capital Management LLC	[2023-03-31]	SOLE	2,014,241.0	2,014,241.0
Suvretta Capital Management LLC	[2023-03-31]	SOLE	1,902,643.0	1,902,643.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,631,906.0
ProSight Management LP	[2023-03-31]	SOLE	1,545,000.0	1,545,000.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	1,435,945.0	1,435,945.0
OrbiMed Advisors LLC	[2023-03-31]	SOLE	1,374,468.0	1,374,468.0
Boxer Capital, LLC	[2023-03-31]	OTR	1,054,000.0	1,054,000.0
Invus Financial Advisors LLC	[2023-03-31]	SOLE	1,007,575.0	1,007,575.0
Euclidean Capital LLC	[2023-03-31]	SOLE	747,550.0	747,550.0
BlackRock Inc.	[2023-03-31]	SOLE	689,132.0	690,514.0
Memorial Sloan Kettering Cancer Center	[2023-03-31]	SOLE	602,272.0	602,272.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	578,303.0	578,303.0
Monaco Asset Management SAM	[2023-03-31]	SOLE	551,749.0	551,749.0
Alkeon Capital Management LLC	[2023-03-31]	OTR	0.0	385,011.0
UBS OConnor LLC	[2023-03-31]	DFND	362,707.0	362,707.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	344,100.0	344,100.0
Geode Capital Management LLC	[2023-03-31]	DFND	307,422.0	307,422.0
Susquehanna International Group LLP	[2023-03-31]	DFND	238,438.0	271,938.0
ArrowMark Colorado Holdings LLC	[2023-03-31]	SOLE	255,732.0	255,732.0
Jane Street Group LLC	[2023-03-31]	DFND	173,159.0	173,159.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	170,326.0	170,326.0
Victory Capital Management Inc	[2023-03-31]	SOLE	158,430.0	158,430.0
GSA Capital Partners LLP	[2023-03-31]	SOLE	142,405.0	142,405.0
Citadel Advisors LLC	[2023-03-31]	DFND	134,903.0	134,903.0
Newtyn Management LLC	[2023-03-31]	SOLE	133,999.0	133,999.0
Acadian Asset Management LLC	[2023-03-31]	DFND	130,655.0	130,655.0
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