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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	14,691,344
FMR LLC	[2025-06-30]	DFND	12,099,875	12,151,050
RA Capital Management LP	[2025-06-30]	SOLE	11,965,991	11,965,991
Vanguard Group Inc	[2025-06-30]	SOLE	0	11,773,010
BlackRock, Inc.	[2025-06-30]	SOLE	10,306,974	10,641,684
Wellington Management Group LLP	[2025-06-30]	DFND	0	4,954,804
State Street Corp	[2025-06-30]	DFND	4,546,013	4,942,235
Capital Research Global Investors	[2025-06-30]	DFND	4,771,786	4,771,786
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	3,372,837	3,372,837
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	3,088,450	3,088,450
Kynam Capital Management LP	[2025-06-30]	SOLE	3,071,588	3,071,588
Westfield Capital Management Co LP	[2025-06-30]	SOLE	2,286,337	3,068,898
Geode Capital Management LLC	[2025-06-30]	DFND	3,011,140	3,011,140
Deep Track Capital LP	[2025-06-30]	SOLE	2,150,000	2,150,000
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,417,711	1,417,711
UBS Group AG	[2025-06-30]	DFND	1,380,845	1,380,853
Maverick Capital Ltd	[2025-06-30]	SOLE	1,310,605	1,310,605
Jennison Associates LLC	[2025-06-30]	DFND	1,306,619	1,307,096
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	1,305,125
Eversept Partners LP	[2025-06-30]	SOLE	1,298,514	1,298,514
Citadel Advisors LLC	[2025-06-30]	DFND	1,205,338	1,205,338
JPMorgan Chase & Co	[2025-06-30]	DFND	1,000,078	1,198,041
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,058,115	1,175,661
Millennium Management LLC	[2025-06-30]	SOLE	1,104,839	1,136,039
Northern Trust Corp	[2025-06-30]	DFND	1,100,839	1,101,872
Bank of America Corp /DE/	[2025-06-30]	DFND	46,581	1,082,671
Norges Bank	[2025-06-30]	SOLE	987,674	987,674
Goldman Sachs Group Inc	[2025-06-30]	DFND	954,783	955,668
Franklin Resources Inc	[2025-06-30]	DFND	936,391	939,275
Novo Holdings A/S	[2025-06-30]	SOLE	916,160	916,160
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