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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	11,806,334.0	11,808,565.0
RA Capital Management LP	[2023-03-31]	SOLE	0.0	7,291,254.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	7,127,611.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	6,347,979.0
BlackRock Inc.	[2023-03-31]	SOLE	5,008,409.0	5,081,865.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	3,239,274.0
State Street Corp	[2023-03-31]	DFND	2,928,728.0	3,076,016.0
Capital Research Global Investors	[2023-03-31]	DFND	2,853,006.0	2,853,006.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	1,923,158.0
Medicxi Ventures Management (Jersey) Ltd	[2023-03-31]	SOLE	1,457,300.0	1,457,300.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	1,397,405.0	1,397,405.0
Jennison Associates LLC	[2023-03-31]	DFND	1,351,848.0	1,351,848.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,329,339.0	1,329,339.0
Braidwell LP	[2023-03-31]	SOLE	1,319,978.0	1,319,978.0
Millennium Management LLC	[2023-03-31]	SOLE	1,313,642.0	1,313,642.0
Kynam Capital Management LP	[2023-03-31]	SOLE	1,216,784.0	1,216,784.0
TPG GP A LLC	[2023-03-31]	DFND	1,190,336.0	1,190,336.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	1,170,000.0	1,170,000.0
Citadel Advisors LLC	[2023-03-31]	DFND	864,410.0	864,410.0
Fred Alger Management LLC	[2023-03-31]	SOLE	822,672.0	844,778.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	794,907.0	794,907.0
Novo Holdings A/S	[2023-03-31]	SOLE	745,000.0	745,000.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	244,202.0	733,907.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	90,600.0	729,439.0
Franklin Resources Inc	[2023-03-31]	DFND	714,448.0	716,239.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	693,039.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	670,084.0
Northern Trust Corp	[2023-03-31]	DFND	39,478.0	667,841.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	659,211.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	502,353.0	613,906.0
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130028125