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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Great Point Partners LLC	[2025-06-30]	SOLE	0	2,645,128
Armistice Capital LLC	[2025-06-30]	SOLE	2,137,896	2,137,896
Sphera Funds Management Ltd	[2025-06-30]	DFND	1,899,297	1,899,297
Ally Bridge Group NY LLC	[2025-06-30]	SOLE	1,334,428	1,334,428
Allostery Investments LP	[2025-06-30]	SOLE	155,720	155,720
Citadel Advisors LLC	[2025-06-30]	DFND	63,429	63,429
Graypoint LLC	[2025-06-30]	SOLE	52,833	52,833
Kingsview Wealth Management LLC	[2025-06-30]	SOLE	0	31,062
Bank of Montreal /Can/	[2025-06-30]	DFND	30,366	30,366
Fiduciary Trust Co	[2025-06-30]	DFND	28,583	28,583
Howard Financial Services Ltd	[2025-06-30]	SOLE	0	26,042
IEQ Capital LLC	[2025-06-30]	SOLE	0	26,042
Scotia Capital Inc	[2025-06-30]	DFND	0	12,122
Commonwealth Equity Services LLC	[2025-06-30]	SOLE	0	11,447
Claret Asset Management Corp	[2025-06-30]	SOLE	11,330	11,330
Royal Bank of Canada	[2025-06-30]	DFND	5,487	5,487
Bank of America Corp /DE/	[2025-06-30]	DFND	1,666	1,666
TD Waterhouse Canada Inc.	[2025-06-30]	DFND	133	133
National Bank of Canada /FI/	[2025-06-30]	DFND	0	88
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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