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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,533,405
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,974,585	1,974,585
Cormorant Asset Management LP	[2025-06-30]	DFND	1,625,000	1,625,000
BlackRock, Inc.	[2025-06-30]	SOLE	1,546,642	1,590,128
Morgan Stanley	[2025-06-30]	DFND	1,225,389	1,226,339
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,184,424
Soleus Capital Management LP	[2025-06-30]	SOLE	966,740	966,740
Point72 Asset Management LP	[2025-06-30]	DFND	0	954,075
Perceptive Advisors LLC	[2025-06-30]	SOLE	752,921	752,921
State Street Corp	[2025-06-30]	DFND	665,988	698,093
Baker Bros Advisors LP	[2025-06-30]	SOLE	689,488	689,488
Deerfield Management Company LP	[2025-06-30]	DFND	686,931	686,931
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	604,298	604,298
Driehaus Capital Management LLC	[2025-06-30]	SOLE	470,424	530,988
Ikarian Capital LLC	[2025-06-30]	SOLE	519,350	519,350
Bank of America Corp /DE/	[2025-06-30]	DFND	3,478	478,403
Geode Capital Management LLC	[2025-06-30]	DFND	451,731	451,731
CIBC Asset Management Inc	[2025-06-30]	SOLE	388,759	388,759
Balyasny Asset Management LP	[2025-06-30]	SOLE	369,254	369,254
Franklin Resources Inc	[2025-06-30]	DFND	314,150	314,150
Susquehanna International Group LLP	[2025-06-30]	OTR	46,927	254,527
Goldman Sachs Group Inc	[2025-06-30]	DFND	225,952	225,992
Logos Global Management LP	[2025-06-30]	SOLE	225,000	225,000
Aberdeen Group plc	[2025-06-30]	DFND	214,056	214,056
Northern Trust Corp	[2025-06-30]	DFND	210,729	210,837
Sphera Funds Management Ltd	[2025-06-30]	DFND	109,757	209,757
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	207,021
TRI Locum Partners LP	[2025-06-30]	SOLE	195,432	195,432
5AM Venture Management LLC	[2025-06-30]	SOLE	170,000	170,000
Vivo Capital LLC	[2025-06-30]	SOLE	167,600	167,600
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