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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,664,554
RTW Investments LP	[2025-06-30]	SOLE	7,746,415	7,746,415
BlackRock, Inc.	[2025-06-30]	SOLE	7,177,243	7,480,432
Armistice Capital LLC	[2025-06-30]	SOLE	4,735,464	4,735,464
Wellington Management Group LLP	[2025-06-30]	DFND	0	4,694,138
Janus Henderson Group PLC	[2025-06-30]	DFND	0	3,175,015
State Street Corp	[2025-06-30]	DFND	2,763,318	2,996,454
Toronto Dominion Bank	[2025-06-30]	DFND	0	2,445,958
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	2,402,582	2,437,697
Geode Capital Management LLC	[2025-06-30]	DFND	1,934,593	1,934,593
FMR LLC	[2025-06-30]	DFND	1,716,002	1,718,287
Bank of America Corp /DE/	[2025-06-30]	DFND	73,961	1,381,408
Franklin Resources Inc	[2025-06-30]	DFND	1,272,390	1,274,760
Morgan Stanley	[2025-06-30]	DFND	1,122,106	1,163,339
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,100,000
Driehaus Capital Management LLC	[2025-06-30]	SOLE	897,555	1,059,026
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	966,726	1,041,431
Nuveen, LLC	[2025-06-30]	DFND	952,867	968,892
Citadel Advisors LLC	[2025-06-30]	DFND	967,393	967,393
Renaissance Technologies LLC	[2025-06-30]	SOLE	963,300	963,300
Rockefeller Capital Management L.P.	[2025-06-30]	DFND	926,158	926,158
Goldman Sachs Group Inc	[2025-06-30]	DFND	771,747	775,753
Pacer Advisors Inc	[2025-06-30]	SOLE	740,817	740,817
Northern Trust Corp	[2025-06-30]	DFND	725,887	726,571
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	707,704	707,704
Man Group plc	[2025-06-30]	DFND	612,103	671,513
Susquehanna International Group LLP	[2025-06-30]	OTR	431,730	642,730
Hood River Capital Management LLC	[2025-06-30]	SOLE	616,503	636,502
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	631,622	631,622
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	605,905	605,905
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