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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Pfizer Inc	[2025-06-30]	SOLE	5,952,263	5,952,263
Laurion Capital Management LP	[2025-06-30]	SOLE	3,625,974	3,625,974
Millennium Management LLC	[2025-06-30]	SOLE	3,539,860	3,539,860
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,500,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,136,337
Pfizer Inc	[2025-06-30]	DFND	0	1,080,507
Palo Alto Investors LP	[2025-06-30]	SOLE	1,037,421	1,037,421
BlackRock, Inc.	[2025-06-30]	SOLE	921,324	926,805
Aberdeen Group plc	[2025-06-30]	DFND	913,045	913,045
683 Capital Management LLC	[2025-06-30]	DFND	545,000	545,000
Geode Capital Management LLC	[2025-06-30]	DFND	510,963	510,963
Renaissance Technologies LLC	[2025-06-30]	SOLE	417,822	417,822
UBS Group AG	[2025-06-30]	DFND	393,296	396,096
Pier 88 Investment Partners LLC	[2025-06-30]	SOLE	367,170	367,170
Jane Street Group LLC	[2025-06-30]	DFND	336,084	336,084
Decheng Capital LLC	[2025-06-30]	SOLE	326,810	326,810
Schulhoff & Co Inc	[2025-06-30]	SOLE	0	275,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	224,274	224,274
State Street Corp	[2025-06-30]	DFND	186,055	186,055
Bank of New York Mellon Corp	[2025-06-30]	DFND	165,044	165,044
Morgan Stanley	[2025-06-30]	DFND	157,224	160,174
Marshall Wace LLP	[2025-06-30]	OTR	0	147,771
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	142,295	142,295
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	133,047	133,047
Newedge Wealth LLC	[2025-06-30]	SOLE	0	116,006
Susquehanna International Group LLP	[2025-06-30]	OTR	114,359	114,359
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	103,063	103,063
Northern Trust Corp	[2025-06-30]	DFND	102,216	102,216
FMR LLC	[2025-06-30]	DFND	82,873	94,846
Royal Bank of Canada	[2025-06-30]	DFND	86,365	86,365
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