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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Viking Global Investors LP	[2025-06-30]	SOLE	4,194,777	4,194,777
Johnson & Johnson	[2025-06-30]	DFND	0	3,636,363
5AM Venture Management LLC	[2025-06-30]	SOLE	3,630,724	3,630,724
New Leaf Venture Partners LLC	[2025-06-30]	DFND	3,301,603	3,301,603
TPG GP A LLC	[2025-06-30]	DFND	3,028,414	3,028,414
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	2,404,644
FMR LLC	[2025-06-30]	DFND	1,870,276	1,870,276
Almitas Capital LLC	[2025-06-30]	SOLE	1,817,492	1,817,492
Aberdeen Group plc	[2025-06-30]	DFND	1,595,262	1,595,262
Canaan Partners XI LLC	[2025-06-30]	SOLE	940,984	940,984
Vanguard Group Inc	[2025-06-30]	SOLE	0	898,405
AJU IB Investment Co., Ltd.	[2025-06-30]	SOLE	754,678	754,678
Laurion Capital Management LP	[2025-06-30]	SOLE	735,543	735,543
Renaissance Technologies LLC	[2025-06-30]	SOLE	485,032	485,032
Mariner LLC	[2025-06-30]	SOLE	0	404,546
Geode Capital Management LLC	[2025-06-30]	DFND	245,009	245,009
Millennium Management LLC	[2025-06-30]	SOLE	179,839	179,839
BlackRock, Inc.	[2025-06-30]	SOLE	154,648	154,648
UBS Group AG	[2025-06-30]	DFND	120,242	120,242
Acadian Asset Management LLC	[2025-06-30]	DFND	90,247	90,247
Two Sigma Advisers LP	[2025-06-30]	SOLE	83,700	88,900
Citadel Advisors LLC	[2025-06-30]	DFND	64,884	64,884
Two Sigma Investments LP	[2025-06-30]	SOLE	63,786	63,786
State Street Corp	[2025-06-30]	DFND	62,072	62,072
Virtu Financial LLC	[2025-06-30]	DFND	56,762	56,762
XTX Topco Ltd	[2025-06-30]	DFND	55,479	55,479
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	40,032
Northern Trust Corp	[2025-06-30]	DFND	38,124	38,124
Morgan Stanley	[2025-06-30]	DFND	36,484	36,484
HRT Financial LP	[2025-06-30]	DFND	29,607	29,607
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