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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Viking Global Investors LP	[2023-03-31]	SOLE	4,194,777.0	4,194,777.0
5AM Venture Management LLC	[2023-03-31]	SOLE	3,630,724.0	3,630,724.0
New Leaf Venture Partners LLC	[2023-03-31]	DFND	3,301,603.0	3,301,603.0
FMR LLC	[2023-03-31]	DFND	3,245,201.0	3,245,255.0
TPG GP A LLC	[2023-03-31]	DFND	3,028,414.0	3,028,414.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	2,404,644.0
Novo Holdings A/S	[2023-03-31]	SOLE	2,270,110.0	2,270,110.0
Canaan Partners XI LLC	[2023-03-31]	SOLE	2,059,712.0	2,059,712.0
Tekla Capital Management LLC	[2023-03-31]	SOLE	9,861,553.0	1,727,067.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	967,460.0
BlackRock Inc.	[2023-03-31]	SOLE	912,922.0	931,495.0
Laurion Capital Management LP	[2023-03-31]	SOLE	783,391.0	783,391.0
CHI Advisors LLC	[2023-03-31]	DFND	760,543.0	760,543.0
Sectoral Asset Management Inc	[2023-03-31]	SOLE	175,977.0	551,937.0
Geode Capital Management LLC	[2023-03-31]	DFND	363,760.0	363,760.0
Citadel Advisors LLC	[2023-03-31]	DFND	353,319.0	353,319.0
State Street Corp	[2023-03-31]	DFND	258,698.0	273,992.0
VR Adviser LLC	[2023-03-31]	SOLE	268,532.0	268,532.0
Vontobel Holding Ltd.	[2023-03-31]	DFND	175,977.0	175,977.0
CaaS Capital Management LP	[2023-03-31]	SOLE	164,328.0	164,328.0
Northern Trust Corp	[2023-03-31]	DFND	2,901.0	154,435.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	54,652.0	54,652.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	47,848.0	51,334.0
JPMorgan Chase & Co	[2023-03-31]	DFND	16,944.0	31,357.0
DekaBank Deutsche Girozentrale	[2023-03-31]	DFND	30,000.0	30,000.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	27,560.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	19,791.0	27,002.0
RhumbLine Advisers	[2023-03-31]	SOLE	9,987.0	23,106.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	22,825.0	22,825.0
HarbourVest Partners LLC	[2023-03-31]	SOLE	21,877.0	21,877.0
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