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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
NEA Management Company LLC	[2023-03-31]	DFND	4,785,494.0	4,785,494.0
Novo Holdings A/S	[2023-03-31]	SOLE	3,430,377.0	3,430,377.0
Rivervest Venture Management LLC	[2023-03-31]	SOLE	2,409,220.0	2,409,220.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	2,073,957.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	1,143,185.0	1,143,185.0
Aisling Capital Management LP	[2023-03-31]	SOLE	886,075.0	886,075.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	420,000.0	420,000.0
Franklin Resources Inc	[2023-03-31]	DFND	407,605.0	407,605.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	314,539.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	245,787.0	245,787.0
Ikarian Capital LLC	[2023-03-31]	SOLE	155,819.0	155,819.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	120,864.0
Geode Capital Management LLC	[2023-03-31]	DFND	96,611.0	96,611.0
Federated Hermes Inc	[2023-03-31]	DFND	78,390.0	78,390.0
Barclays PLC	[2023-03-31]	SOLE	71,930.0	71,930.0
MAI Capital Management	[2023-03-31]	SOLE	41,304.0	53,428.0
UBS Group AG	[2023-03-31]	SOLE	52,961.0	52,961.0
Morgan Stanley	[2023-03-31]	DFND	42,329.0	42,329.0
Susquehanna International Group LLP	[2023-03-31]	DFND	32,358.0	32,358.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	28,696.0	28,696.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	25,600.0	25,600.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	25,000.0	25,000.0
Millennium Management LLC	[2023-03-31]	SOLE	23,935.0	23,935.0
BlackRock Inc.	[2023-03-31]	SOLE	23,637.0	23,637.0
Commonwealth Equity Services LLC	[2023-03-31]	SOLE	0.0	22,347.0
JPMorgan Chase & Co	[2023-03-31]	DFND	19,776.0	19,776.0
Jane Street Group LLC	[2023-03-31]	DFND	19,743.0	19,743.0
State Street Corp	[2023-03-31]	DFND	16,400.0	16,400.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	15,967.0
Northern Trust Corp	[2023-03-31]	DFND	185.0	15,032.0
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