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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	3,702,967	3,702,967
BlackRock, Inc.	[2025-06-30]	SOLE	2,919,038	3,007,110
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	2,041,668	2,252,544
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,201,098
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	1,308,130	1,321,330
Deutsche Bank AG	[2025-06-30]	DFND	720	1,229,262
No Street GP LP	[2025-06-30]	SOLE	1,200,000	1,200,000
Brown Capital Management LLC	[2025-06-30]	SOLE	494,750	1,119,240
Citadel Advisors LLC	[2025-06-30]	DFND	1,078,363	1,078,363
Morgan Stanley	[2025-06-30]	DFND	938,338	1,001,723
Millennium Management LLC	[2025-06-30]	SOLE	951,177	951,177
State Street Corp	[2025-06-30]	DFND	842,361	916,215
Deerfield Management Company LP	[2025-06-30]	DFND	888,950	888,950
Geode Capital Management LLC	[2025-06-30]	DFND	862,669	862,669
Wellington Management Group LLP	[2025-06-30]	DFND	0	727,952
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	633,874	633,874
Royal Bank of Canada	[2025-06-30]	DFND	35,068	529,225
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	481,064
New York State Common Retirement Fund	[2025-06-30]	SOLE	466,923	466,923
Wasatch Advisors LP	[2025-06-30]	SOLE	448,539	448,539
Two Sigma Investments LP	[2025-06-30]	SOLE	440,456	440,456
Renaissance Technologies LLC	[2025-06-30]	SOLE	426,400	426,400
Voloridge Investment Management LLC	[2025-06-30]	SOLE	401,635	401,635
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	386,210	386,210
Squarepoint Ops LLC	[2025-06-30]	DFND	0	374,663
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	332,823	365,364
Northern Trust Corp	[2025-06-30]	DFND	335,777	335,777
Baillie Gifford & Co	[2025-06-30]	DFND	310,092	310,092
Kent Lake PR LLC	[2025-06-30]	SOLE	300,000	300,000
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	292,317	292,317
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